Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045066366> ?p ?o ?g. }
- W2045066366 endingPage "1238" @default.
- W2045066366 startingPage "1226" @default.
- W2045066366 abstract "The intestinal epithelium is the most rapidly self-renewing tissue in adult animals and maintained by intestinal stem cells (ISCs) in both Drosophila and mammals. To comprehensively identify genes and pathways that regulate ISC fates, we performed a genome-wide transgenic RNAi screen in adult Drosophila intestine and identified 405 genes that regulate ISC maintenance and lineage-specific differentiation. By integrating these genes into publicly available interaction databases, we further developed functional networks that regulate ISC self-renewal, ISC proliferation, ISC maintenance of diploid status, ISC survival, ISC-to-enterocyte (EC) lineage differentiation, and ISC-to-enteroendocrine (EE) lineage differentiation. By comparing regulators among ISCs, female germline stem cells, and neural stem cells, we found that factors related to basic stem cell cellular processes are commonly required in all stem cells, and stem-cell-specific, niche-related signals are required only in the unique stem cell type. Our findings provide valuable insights into stem cell maintenance and lineage-specific differentiation." @default.
- W2045066366 created "2016-06-24" @default.
- W2045066366 creator A5004585142 @default.
- W2045066366 creator A5009824466 @default.
- W2045066366 creator A5018171580 @default.
- W2045066366 creator A5025902765 @default.
- W2045066366 creator A5041405608 @default.
- W2045066366 creator A5053323483 @default.
- W2045066366 creator A5059834789 @default.
- W2045066366 creator A5060002817 @default.
- W2045066366 creator A5064240182 @default.
- W2045066366 creator A5071037763 @default.
- W2045066366 creator A5080862307 @default.
- W2045066366 date "2015-02-01" @default.
- W2045066366 modified "2023-10-17" @default.
- W2045066366 title "Genome-wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila" @default.
- W2045066366 cites W1968112233 @default.
- W2045066366 cites W1971571526 @default.
- W2045066366 cites W1976557090 @default.
- W2045066366 cites W1977646726 @default.
- W2045066366 cites W1977962361 @default.
- W2045066366 cites W1979159320 @default.
- W2045066366 cites W1985234259 @default.
- W2045066366 cites W1986364178 @default.
- W2045066366 cites W1986932941 @default.
- W2045066366 cites W1987637982 @default.
- W2045066366 cites W1987919833 @default.
- W2045066366 cites W1991691876 @default.
- W2045066366 cites W2006229889 @default.
- W2045066366 cites W2009397177 @default.
- W2045066366 cites W2010605216 @default.
- W2045066366 cites W2011272466 @default.
- W2045066366 cites W2011751354 @default.
- W2045066366 cites W2013123192 @default.
- W2045066366 cites W2014137007 @default.
- W2045066366 cites W2017691917 @default.
- W2045066366 cites W2020969391 @default.
- W2045066366 cites W2028133785 @default.
- W2045066366 cites W2030791386 @default.
- W2045066366 cites W2032015210 @default.
- W2045066366 cites W2035704783 @default.
- W2045066366 cites W2037598426 @default.
- W2045066366 cites W2043458004 @default.
- W2045066366 cites W2051909115 @default.
- W2045066366 cites W2052543023 @default.
- W2045066366 cites W2053352622 @default.
- W2045066366 cites W2054636918 @default.
- W2045066366 cites W2064578610 @default.
- W2045066366 cites W2064632705 @default.
- W2045066366 cites W2065653828 @default.
- W2045066366 cites W2070386387 @default.
- W2045066366 cites W2071608742 @default.
- W2045066366 cites W2073594767 @default.
- W2045066366 cites W2073609428 @default.
- W2045066366 cites W2075230979 @default.
- W2045066366 cites W2079657320 @default.
- W2045066366 cites W2081092282 @default.
- W2045066366 cites W2082867955 @default.
- W2045066366 cites W2091883691 @default.
- W2045066366 cites W2091998897 @default.
- W2045066366 cites W2096611052 @default.
- W2045066366 cites W2099991247 @default.
- W2045066366 cites W2105575647 @default.
- W2045066366 cites W2106702454 @default.
- W2045066366 cites W2111993114 @default.
- W2045066366 cites W2112743993 @default.
- W2045066366 cites W2114830509 @default.
- W2045066366 cites W2118810801 @default.
- W2045066366 cites W2119021294 @default.
- W2045066366 cites W2120132994 @default.
- W2045066366 cites W2125987139 @default.
- W2045066366 cites W2126471829 @default.
- W2045066366 cites W2131007219 @default.
- W2045066366 cites W2132394675 @default.
- W2045066366 cites W2132605861 @default.
- W2045066366 cites W2133943800 @default.
- W2045066366 cites W2142018200 @default.
- W2045066366 cites W2142360030 @default.
- W2045066366 cites W2145955680 @default.
- W2045066366 cites W2150972545 @default.
- W2045066366 cites W2155111434 @default.
- W2045066366 cites W2155446514 @default.
- W2045066366 cites W2159695068 @default.
- W2045066366 cites W2160513335 @default.
- W2045066366 cites W2161092951 @default.
- W2045066366 cites W2162421238 @default.
- W2045066366 cites W2166781358 @default.
- W2045066366 doi "https://doi.org/10.1016/j.celrep.2015.01.051" @default.
- W2045066366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4420031" @default.
- W2045066366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25704823" @default.
- W2045066366 hasPublicationYear "2015" @default.
- W2045066366 type Work @default.
- W2045066366 sameAs 2045066366 @default.
- W2045066366 citedByCount "83" @default.
- W2045066366 countsByYear W20450663662015 @default.
- W2045066366 countsByYear W20450663662016 @default.
- W2045066366 countsByYear W20450663662017 @default.
- W2045066366 countsByYear W20450663662018 @default.