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- W2045074452 abstract "Abstract Background The high rate of morbidity and mortality resulting from long‐term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. Aims This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV. Methods In a double‐blind, placebo‐controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared. Results The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 ± 1.7 vs. 24.4 ± 3.3, P < 0.001). Conclusions Pilocarpine gel effectively treats PV." @default.
- W2045074452 created "2016-06-24" @default.
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- W2045074452 date "2006-01-17" @default.
- W2045074452 modified "2023-10-10" @default.
- W2045074452 title "Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris" @default.
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- W2045074452 doi "https://doi.org/10.1111/j.1365-4632.2006.02766.x" @default.
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