Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045075357> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2045075357 endingPage "212" @default.
- W2045075357 startingPage "205" @default.
- W2045075357 abstract "The effect of ergotamine on the isolated rat stomach and its influence on the response to ACh and 5-HT were investigated. The log dose-response curve of ergotamine was bell-shaped. Extension of the incubation time of ergotamine resulted in a parallel shift to the left of the curve. The response to ergotamine was inhibited by methyserigide and piperoxan. Incubation with ergotamine resulted in a decrease of the pD2-value of 5-HT together with a marked suppression of the maximum of the 5-HT curve. The response to ACh was affected in accordance with the prediction of an action of ACh and ergotamine on different receptors. The prolonged receptor stimulation by 5-HT or ACh resulted in a decrease of the apparent affinity towards their receptors. Incubation with ACh resulted in a parallel shift to the right of the 5-HT curve. However no inconsistency with the theoretical prediction of an action on separate receptors was observed with the ACh curve in the presence of 5-HT. It is concluded that ergotamine is a partial agonist on the D-tryptamine receptors of tbe isolated rat stomach. The marked decrease of the maximum of the 5-HT curve by ergotamine is probably caused by the slowly reversible character of its antagonism. The parallel shift to the left of the ergotamine curve with the extension of the incubation time and the persistence of its antagonism both are probably caused by a slow diffusion into and from the biophase." @default.
- W2045075357 created "2016-06-24" @default.
- W2045075357 creator A5057541333 @default.
- W2045075357 date "1975-02-01" @default.
- W2045075357 modified "2023-10-06" @default.
- W2045075357 title "Analysis of ergotamine — 5-HT interaction on the isolated rat stomach preparation" @default.
- W2045075357 cites W1521991778 @default.
- W2045075357 cites W1598269312 @default.
- W2045075357 cites W2001000139 @default.
- W2045075357 cites W2003033259 @default.
- W2045075357 cites W2009285843 @default.
- W2045075357 cites W2015574004 @default.
- W2045075357 cites W2028151934 @default.
- W2045075357 cites W2032361350 @default.
- W2045075357 cites W2057710947 @default.
- W2045075357 cites W2058505890 @default.
- W2045075357 cites W2082745673 @default.
- W2045075357 cites W2090888013 @default.
- W2045075357 cites W2113897056 @default.
- W2045075357 cites W2154121435 @default.
- W2045075357 doi "https://doi.org/10.1016/0014-2999(75)90101-6" @default.
- W2045075357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1126359" @default.
- W2045075357 hasPublicationYear "1975" @default.
- W2045075357 type Work @default.
- W2045075357 sameAs 2045075357 @default.
- W2045075357 citedByCount "10" @default.
- W2045075357 countsByYear W20450753572013 @default.
- W2045075357 crossrefType "journal-article" @default.
- W2045075357 hasAuthorship W2045075357A5057541333 @default.
- W2045075357 hasConcept C126322002 @default.
- W2045075357 hasConcept C134018914 @default.
- W2045075357 hasConcept C170493617 @default.
- W2045075357 hasConcept C185592680 @default.
- W2045075357 hasConcept C24998067 @default.
- W2045075357 hasConcept C2775864247 @default.
- W2045075357 hasConcept C2777383412 @default.
- W2045075357 hasConcept C2778541695 @default.
- W2045075357 hasConcept C2778938600 @default.
- W2045075357 hasConcept C2779929513 @default.
- W2045075357 hasConcept C55493867 @default.
- W2045075357 hasConcept C71924100 @default.
- W2045075357 hasConcept C86803240 @default.
- W2045075357 hasConcept C98274493 @default.
- W2045075357 hasConceptScore W2045075357C126322002 @default.
- W2045075357 hasConceptScore W2045075357C134018914 @default.
- W2045075357 hasConceptScore W2045075357C170493617 @default.
- W2045075357 hasConceptScore W2045075357C185592680 @default.
- W2045075357 hasConceptScore W2045075357C24998067 @default.
- W2045075357 hasConceptScore W2045075357C2775864247 @default.
- W2045075357 hasConceptScore W2045075357C2777383412 @default.
- W2045075357 hasConceptScore W2045075357C2778541695 @default.
- W2045075357 hasConceptScore W2045075357C2778938600 @default.
- W2045075357 hasConceptScore W2045075357C2779929513 @default.
- W2045075357 hasConceptScore W2045075357C55493867 @default.
- W2045075357 hasConceptScore W2045075357C71924100 @default.
- W2045075357 hasConceptScore W2045075357C86803240 @default.
- W2045075357 hasConceptScore W2045075357C98274493 @default.
- W2045075357 hasIssue "2" @default.
- W2045075357 hasLocation W20450753571 @default.
- W2045075357 hasLocation W20450753572 @default.
- W2045075357 hasOpenAccess W2045075357 @default.
- W2045075357 hasPrimaryLocation W20450753571 @default.
- W2045075357 hasRelatedWork W1989897914 @default.
- W2045075357 hasRelatedWork W2056856680 @default.
- W2045075357 hasRelatedWork W2066312209 @default.
- W2045075357 hasRelatedWork W2068151254 @default.
- W2045075357 hasRelatedWork W2089229336 @default.
- W2045075357 hasRelatedWork W2139242471 @default.
- W2045075357 hasRelatedWork W2193386695 @default.
- W2045075357 hasRelatedWork W2405091648 @default.
- W2045075357 hasRelatedWork W2582945263 @default.
- W2045075357 hasRelatedWork W2794143596 @default.
- W2045075357 hasVolume "30" @default.
- W2045075357 isParatext "false" @default.
- W2045075357 isRetracted "false" @default.
- W2045075357 magId "2045075357" @default.
- W2045075357 workType "article" @default.