FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045095436> ?p ?o ?g. }

• W2045095436 endingPage "e1703" @default.
• W2045095436 startingPage "e1703" @default.
• W2045095436 abstract "Abstract The high mortality in breast cancer is often associated with metastatic progression in patients. Previously we have demonstrated that testes-specific protease 50 (TSP50), an oncogene overexpressed in breast cancer samples, could promote cell proliferation and tumorigenesis. However, whether TSP50 also has a key role in cell invasion and cancer metastasis, and the mechanism underlying the process are still unclear. Here we found that TSP50 overexpression greatly promoted cell migration, invasion, adhesion and formation of the stellate structures in 3D culture system in vitro as well as lung metastasis in vivo . Conversely, TSP50 knockdown caused the opposite changes. Mechanistic studies revealed that NF- κ B signaling pathway was required for TSP50-induced cell migration and metastasis, and further results indicated that TSP50 overexpression enhanced expression and secretion of MMP9, a target gene of NF- κ B signaling. In addition, knockdown of MMP9 resulted in inhibition of cell migration and invasion in vitro and lung metastasis in vivo . Most importantly, immunohistochemical staining of human breast cancer samples strongly showed that the coexpression of TSP50 and p65 as well as TSP50 and MMP9 were correlated with increased metastasis and poor survival. Furthermore, we found that some breast cancer diagnosis-associated features such as tumor size, tumor grade, estrogen receptors (ER) and progesterone receptors (PR) levels, were correlated well with TSP50/p65 and TSP50/MMP9 expression status. Taken together, this work identified the TSP50 activation of MMP9 as a novel signaling mechanism underlying human breast cancer invasion and metastasis." @default.
• W2045095436 created "2016-06-24" @default.
• W2045095436 creator A5017878880 @default.
• W2045095436 creator A5018942228 @default.
• W2045095436 creator A5021565597 @default.
• W2045095436 creator A5026345350 @default.
• W2045095436 creator A5029567042 @default.
• W2045095436 creator A5030362253 @default.
• W2045095436 creator A5044768184 @default.
• W2045095436 creator A5052338474 @default.
• W2045095436 creator A5065172791 @default.
• W2045095436 creator A5067697887 @default.
• W2045095436 creator A5089146826 @default.
• W2045095436 date "2015-03-26" @default.
• W2045095436 modified "2023-10-10" @default.
• W2045095436 title "Testes-specific protease 50 promotes cell invasion and metastasis by increasing NF-kappaB-dependent matrix metalloproteinase-9 expression" @default.
• W2045095436 cites W146600679 @default.
• W2045095436 cites W1886431664 @default.
• W2045095436 cites W1967244662 @default.
• W2045095436 cites W1980897622 @default.
• W2045095436 cites W1981584534 @default.
• W2045095436 cites W1984483611 @default.
• W2045095436 cites W1986884128 @default.
• W2045095436 cites W1988390261 @default.
• W2045095436 cites W1995224853 @default.
• W2045095436 cites W1996610886 @default.
• W2045095436 cites W1997574274 @default.
• W2045095436 cites W2007897263 @default.
• W2045095436 cites W2019507706 @default.
• W2045095436 cites W2026145579 @default.
• W2045095436 cites W2026632078 @default.
• W2045095436 cites W2030103715 @default.
• W2045095436 cites W2033961200 @default.
• W2045095436 cites W2035078133 @default.
• W2045095436 cites W2037301800 @default.
• W2045095436 cites W2039658833 @default.
• W2045095436 cites W2043434733 @default.
• W2045095436 cites W2044063668 @default.
• W2045095436 cites W2046646461 @default.
• W2045095436 cites W2061695655 @default.
• W2045095436 cites W2074187493 @default.
• W2045095436 cites W2077994276 @default.
• W2045095436 cites W2080040408 @default.
• W2045095436 cites W2082344537 @default.
• W2045095436 cites W2084867085 @default.
• W2045095436 cites W2084883771 @default.
• W2045095436 cites W2088667932 @default.
• W2045095436 cites W2090688567 @default.
• W2045095436 cites W2096947261 @default.
• W2045095436 cites W2100699016 @default.
• W2045095436 cites W2109509842 @default.
• W2045095436 cites W2109658199 @default.
• W2045095436 cites W2114458415 @default.
• W2045095436 cites W2121098539 @default.
• W2045095436 cites W2134771624 @default.
• W2045095436 cites W2156293127 @default.
• W2045095436 cites W2158008521 @default.
• W2045095436 cites W2161892290 @default.
• W2045095436 cites W2165226571 @default.
• W2045095436 cites W2166452296 @default.
• W2045095436 cites W2170398003 @default.
• W2045095436 cites W2171865516 @default.
• W2045095436 cites W2332258267 @default.
• W2045095436 cites W4312567304 @default.
• W2045095436 doi "https://doi.org/10.1038/cddis.2015.61" @default.
• W2045095436 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4385939" @default.
• W2045095436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25811800" @default.
• W2045095436 hasPublicationYear "2015" @default.
• W2045095436 type Work @default.
• W2045095436 sameAs 2045095436 @default.
• W2045095436 citedByCount "38" @default.
• W2045095436 countsByYear W20450954362015 @default.
• W2045095436 countsByYear W20450954362016 @default.
• W2045095436 countsByYear W20450954362017 @default.
• W2045095436 countsByYear W20450954362018 @default.
• W2045095436 countsByYear W20450954362019 @default.
• W2045095436 countsByYear W20450954362020 @default.
• W2045095436 countsByYear W20450954362021 @default.
• W2045095436 countsByYear W20450954362022 @default.
• W2045095436 countsByYear W20450954362023 @default.
• W2045095436 crossrefType "journal-article" @default.
• W2045095436 hasAuthorship W2045095436A5017878880 @default.
• W2045095436 hasAuthorship W2045095436A5018942228 @default.
• W2045095436 hasAuthorship W2045095436A5021565597 @default.
• W2045095436 hasAuthorship W2045095436A5026345350 @default.
• W2045095436 hasAuthorship W2045095436A5029567042 @default.
• W2045095436 hasAuthorship W2045095436A5030362253 @default.
• W2045095436 hasAuthorship W2045095436A5044768184 @default.
• W2045095436 hasAuthorship W2045095436A5052338474 @default.
• W2045095436 hasAuthorship W2045095436A5065172791 @default.
• W2045095436 hasAuthorship W2045095436A5067697887 @default.
• W2045095436 hasAuthorship W2045095436A5089146826 @default.
• W2045095436 hasBestOaLocation W20450954361 @default.
• W2045095436 hasConcept C104317684 @default.
• W2045095436 hasConcept C121608353 @default.
• W2045095436 hasConcept C126322002 @default.
• W2045095436 hasConcept C127561419 @default.
• W2045095436 hasConcept C137738243 @default.

• next