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- W2045100125 abstract "Type I interferons (IFNs) are our first line of defense against virus infection. Recent studies have suggested the ability of SARS-CoV-2 proteins to inhibit IFN responses. Emerging data also suggest that timing and extent of IFN production is associated with manifestation of COVID-19 severity. In spite of progress in understanding how SARS-CoV-2 activates antiviral responses, mechanistic studies into wild-type SARS-CoV-2-mediated induction and inhibition of human type I IFN responses are scarce. Here we demonstrate that SARS-CoV-2 infection induces a type I IFN response in vitro and in moderate cases of COVID-19. In vitro stimulation of type I IFN expression and signaling in human airway epithelial cells is associated with activation of canonical transcriptions factors, and SARS-CoV-2 is unable to inhibit exogenous induction of these responses. Furthermore, we show that physiological levels of IFNα detected in patients with moderate COVID-19 is sufficient to suppress SARS-CoV-2 replication in human airway cells." @default.
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- W2045100125 date "2008-10-01" @default.
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- W2045100125 title "A recombinant humanized monoclonal antibody to Venezuelan equine encephalitis virus E2 that neutralizes virus in vitro and is effective prophylactically in vivo" @default.
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- W2045100125 doi "https://doi.org/10.1016/j.jbiotec.2008.07.416" @default.
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