FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045100170> ?p ?o ?g. }

• W2045100170 endingPage "2738" @default.
• W2045100170 startingPage "2725" @default.
• W2045100170 abstract "To better understand the roles of TGF-β in bone metabolism, we investigated osteoclast survival in response TGF-β and found that TGF-β inhibited apoptosis. We examined the receptors involved in promotion of osteoclast survival and found that the canonical TGF-β receptor complex is involved in the survival response. The upstream MEK kinase TAK1 was rapidly activated following TGF-β treatment. Since osteoclast survival involves MEK, AKT, and NFκB activation, we examined TGF-β effects on activation of these pathways and observed rapid phosphorylation of MEK, AKT, IKK, IκB, and NFκB. The timing of activation coincided with SMAD activation and dominant negative SMAD expression did not inhibit NFκB activation, indicating that kinase pathway activation is independent of SMAD signaling. Inhibition of TAK1, MEK, AKT, NIK, IKK, or NFκB repressed TGF-β-mediated osteoclast survival. Adenoviral-mediated TAK1 or MEK inhibition eliminated TGF-β-mediated kinase pathway activation and constitutively active AKT expression overcame apoptosis induction following MEK inhibition. TAK1/MEK activation induces pro-survival BclXL expression and TAK1/MEK and SMAD pathway activation induces pro-survival Mcl-1 expression. These data show that TGF-β-induced NFκB activation is through TAK1/MEK-mediated AKT activation, which is essential for TGF-β to support of osteoclast survival." @default.
• W2045100170 created "2016-06-24" @default.
• W2045100170 creator A5016251061 @default.
• W2045100170 creator A5016434083 @default.
• W2045100170 creator A5058026351 @default.
• W2045100170 creator A5071863751 @default.
• W2045100170 creator A5081130714 @default.
• W2045100170 creator A5081195550 @default.
• W2045100170 date "2008-09-01" @default.
• W2045100170 modified "2023-10-16" @default.
• W2045100170 title "TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival" @default.
• W2045100170 cites W1514512256 @default.
• W2045100170 cites W1636022999 @default.
• W2045100170 cites W1860281141 @default.
• W2045100170 cites W1974926454 @default.
• W2045100170 cites W1981579706 @default.
• W2045100170 cites W1982514635 @default.
• W2045100170 cites W1985604953 @default.
• W2045100170 cites W1993844758 @default.
• W2045100170 cites W1994738588 @default.
• W2045100170 cites W1996069571 @default.
• W2045100170 cites W1996409310 @default.
• W2045100170 cites W1996507481 @default.
• W2045100170 cites W2005792688 @default.
• W2045100170 cites W2016674232 @default.
• W2045100170 cites W2017302703 @default.
• W2045100170 cites W2019638983 @default.
• W2045100170 cites W2027872174 @default.
• W2045100170 cites W2040032327 @default.
• W2045100170 cites W2040737652 @default.
• W2045100170 cites W2042773343 @default.
• W2045100170 cites W2043164695 @default.
• W2045100170 cites W2044399712 @default.
• W2045100170 cites W2047956044 @default.
• W2045100170 cites W2049663776 @default.
• W2045100170 cites W2050251876 @default.
• W2045100170 cites W2051437094 @default.
• W2045100170 cites W2051553382 @default.
• W2045100170 cites W2064253775 @default.
• W2045100170 cites W2064439294 @default.
• W2045100170 cites W2065784567 @default.
• W2045100170 cites W2066024775 @default.
• W2045100170 cites W2066153697 @default.
• W2045100170 cites W2066884920 @default.
• W2045100170 cites W2069414088 @default.
• W2045100170 cites W2071536915 @default.
• W2045100170 cites W2071619258 @default.
• W2045100170 cites W2075671160 @default.
• W2045100170 cites W2078296041 @default.
• W2045100170 cites W2082867992 @default.
• W2045100170 cites W2083549154 @default.
• W2045100170 cites W2084662323 @default.
• W2045100170 cites W2097592282 @default.
• W2045100170 cites W2101195856 @default.
• W2045100170 cites W2114933167 @default.
• W2045100170 cites W2117200840 @default.
• W2045100170 cites W2117814548 @default.
• W2045100170 cites W2120376520 @default.
• W2045100170 cites W2124482434 @default.
• W2045100170 cites W2133193835 @default.
• W2045100170 cites W2144206769 @default.
• W2045100170 cites W2147822875 @default.
• W2045100170 cites W2155868854 @default.
• W2045100170 cites W2156436523 @default.
• W2045100170 cites W2161452134 @default.
• W2045100170 cites W2163059327 @default.
• W2045100170 cites W2315471026 @default.
• W2045100170 cites W4256409628 @default.
• W2045100170 doi "https://doi.org/10.1016/j.yexcr.2008.06.006" @default.
• W2045100170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2578840" @default.
• W2045100170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18586026" @default.
• W2045100170 hasPublicationYear "2008" @default.
• W2045100170 type Work @default.
• W2045100170 sameAs 2045100170 @default.
• W2045100170 citedByCount "155" @default.
• W2045100170 countsByYear W20451001702012 @default.
• W2045100170 countsByYear W20451001702013 @default.
• W2045100170 countsByYear W20451001702014 @default.
• W2045100170 countsByYear W20451001702015 @default.
• W2045100170 countsByYear W20451001702016 @default.
• W2045100170 countsByYear W20451001702017 @default.
• W2045100170 countsByYear W20451001702018 @default.
• W2045100170 countsByYear W20451001702019 @default.
• W2045100170 countsByYear W20451001702020 @default.
• W2045100170 countsByYear W20451001702021 @default.
• W2045100170 countsByYear W20451001702022 @default.
• W2045100170 countsByYear W20451001702023 @default.
• W2045100170 crossrefType "journal-article" @default.
• W2045100170 hasAuthorship W2045100170A5016251061 @default.
• W2045100170 hasAuthorship W2045100170A5016434083 @default.
• W2045100170 hasAuthorship W2045100170A5058026351 @default.
• W2045100170 hasAuthorship W2045100170A5071863751 @default.
• W2045100170 hasAuthorship W2045100170A5081130714 @default.
• W2045100170 hasAuthorship W2045100170A5081195550 @default.
• W2045100170 hasBestOaLocation W20451001702 @default.
• W2045100170 hasConcept C100175707 @default.
• W2045100170 hasConcept C11960822 @default.
• W2045100170 hasConcept C170493617 @default.

• next