FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045100899> ?p ?o ?g. }

• W2045100899 endingPage "6065" @default.
• W2045100899 startingPage "6056" @default.
• W2045100899 abstract "Rpb8p, a subunit common to the three yeast RNA polymerases, is conserved among eukaryotes and absent from noneukaryotes. Defective mutants were found at an invariant GGLLM motif and at two other highly conserved amino acids. With one exception, they are clustered on the Rpb8p structure. They all impair a two-hybrid interaction with a fragment conserved in the largest subunits of RNA polymerases I (Rpa190p), II (Rpb1p), and III (Rpc160p). This fragment corresponds to the pore 1 module of the RNA polymerase II crystal structure and bears a highly conserved motif (P.I.KP..LW.GKQ) facing the GGLLM motif of Rpb8p. An RNA polymerase I mutant (rpa190-G728D) at the invariant glycyl of P.I.KP..LW.GKQ provokes a temperature-sensitive defect. Increasing the gene dosage of another common subunit, Rpb6p, suppresses this phenotype. It also suppresses a conditional growth defect observed when replacing Rpb8p by its human counterpart. Hence, Rpb6p and Rpb8p functionally interact in vivo. These two subunits are spatially separated by the pore 1 module and may also be possibly connected by the disorganized N half of Rpb6p, not included in the present structure data. Human Rpb6p is phosphorylated at its N-terminal Ser2, but an alanyl replacement at this position still complements an rpb6-Δ null allele. A two-hybrid interaction also occurs between Rpb8p and the product of orphan geneYGR089w. A ygr089-Δ null mutant has no detectable growth defect but aggravates the conditional growth defect of rpb8 mutants, suggesting that the interaction with Rpb8p may be physiologically relevant." @default.
• W2045100899 created "2016-06-24" @default.
• W2045100899 creator A5005877446 @default.
• W2045100899 creator A5029959217 @default.
• W2045100899 creator A5030031863 @default.
• W2045100899 creator A5032369856 @default.
• W2045100899 creator A5035322069 @default.
• W2045100899 creator A5050773941 @default.
• W2045100899 creator A5051662061 @default.
• W2045100899 creator A5085772599 @default.
• W2045100899 date "2001-09-01" @default.
• W2045100899 modified "2023-09-29" @default.
• W2045100899 title "Partners of Rpb8p, a Small Subunit Shared by Yeast RNA Polymerases I, II, and III" @default.
• W2045100899 cites W1502003464 @default.
• W2045100899 cites W1507350940 @default.
• W2045100899 cites W1518824278 @default.
• W2045100899 cites W1520930575 @default.
• W2045100899 cites W1575827160 @default.
• W2045100899 cites W158539957 @default.
• W2045100899 cites W1903941098 @default.
• W2045100899 cites W1966777673 @default.
• W2045100899 cites W1967271000 @default.
• W2045100899 cites W1974204350 @default.
• W2045100899 cites W1977461004 @default.
• W2045100899 cites W1977889868 @default.
• W2045100899 cites W1989650768 @default.
• W2045100899 cites W1991052006 @default.
• W2045100899 cites W2005744558 @default.
• W2045100899 cites W2006062026 @default.
• W2045100899 cites W2009035150 @default.
• W2045100899 cites W2009229623 @default.
• W2045100899 cites W2013364283 @default.
• W2045100899 cites W2021683023 @default.
• W2045100899 cites W2025498425 @default.
• W2045100899 cites W2053177462 @default.
• W2045100899 cites W2063291840 @default.
• W2045100899 cites W2064010280 @default.
• W2045100899 cites W2074206760 @default.
• W2045100899 cites W2080138031 @default.
• W2045100899 cites W2082328577 @default.
• W2045100899 cites W2085452628 @default.
• W2045100899 cites W2087576311 @default.
• W2045100899 cites W2088808837 @default.
• W2045100899 cites W2090678715 @default.
• W2045100899 cites W2106064022 @default.
• W2045100899 cites W2107870109 @default.
• W2045100899 cites W2115807388 @default.
• W2045100899 cites W2118417249 @default.
• W2045100899 cites W2119707815 @default.
• W2045100899 cites W2137643785 @default.
• W2045100899 cites W2142718407 @default.
• W2045100899 cites W2143121662 @default.
• W2045100899 cites W2155149191 @default.
• W2045100899 cites W237364468 @default.
• W2045100899 cites W4248302271 @default.
• W2045100899 doi "https://doi.org/10.1128/mcb.21.17.6056-6065.2001" @default.
• W2045100899 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/87322" @default.
• W2045100899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11486042" @default.
• W2045100899 hasPublicationYear "2001" @default.
• W2045100899 type Work @default.
• W2045100899 sameAs 2045100899 @default.
• W2045100899 citedByCount "35" @default.
• W2045100899 countsByYear W20451008992012 @default.
• W2045100899 countsByYear W20451008992017 @default.
• W2045100899 countsByYear W20451008992018 @default.
• W2045100899 countsByYear W20451008992020 @default.
• W2045100899 countsByYear W20451008992021 @default.
• W2045100899 countsByYear W20451008992023 @default.
• W2045100899 crossrefType "journal-article" @default.
• W2045100899 hasAuthorship W2045100899A5005877446 @default.
• W2045100899 hasAuthorship W2045100899A5029959217 @default.
• W2045100899 hasAuthorship W2045100899A5030031863 @default.
• W2045100899 hasAuthorship W2045100899A5032369856 @default.
• W2045100899 hasAuthorship W2045100899A5035322069 @default.
• W2045100899 hasAuthorship W2045100899A5050773941 @default.
• W2045100899 hasAuthorship W2045100899A5051662061 @default.
• W2045100899 hasAuthorship W2045100899A5085772599 @default.
• W2045100899 hasBestOaLocation W20451008992 @default.
• W2045100899 hasConcept C104292427 @default.
• W2045100899 hasConcept C104317684 @default.
• W2045100899 hasConcept C143065580 @default.
• W2045100899 hasConcept C153911025 @default.
• W2045100899 hasConcept C2776449523 @default.
• W2045100899 hasConcept C54355233 @default.
• W2045100899 hasConcept C67705224 @default.
• W2045100899 hasConcept C82381507 @default.
• W2045100899 hasConcept C86803240 @default.
• W2045100899 hasConceptScore W2045100899C104292427 @default.
• W2045100899 hasConceptScore W2045100899C104317684 @default.
• W2045100899 hasConceptScore W2045100899C143065580 @default.
• W2045100899 hasConceptScore W2045100899C153911025 @default.
• W2045100899 hasConceptScore W2045100899C2776449523 @default.
• W2045100899 hasConceptScore W2045100899C54355233 @default.
• W2045100899 hasConceptScore W2045100899C67705224 @default.
• W2045100899 hasConceptScore W2045100899C82381507 @default.
• W2045100899 hasConceptScore W2045100899C86803240 @default.
• W2045100899 hasIssue "17" @default.
• W2045100899 hasLocation W20451008991 @default.

• next