FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045103418> ?p ?o ?g. }

• W2045103418 endingPage "101" @default.
• W2045103418 startingPage "94" @default.
• W2045103418 abstract "Standard treatment of acute poisoning by organophosphorus compounds (OP) includes administration of an antimuscarinic (e.g. atropine) and of an oxime-based reactivator of OP-inhibited acetylcholinesterase (AChE). A recently introduced dynamically working in vitro model with real-time determination of membrane-bound AChE activity was shown to be a very versatile and promising model to investigate oxime-induced reactivation kinetics of OP-inhibited enzyme. In this assay, human AChE from erythrocytes or muscle tissue was immobilized on a particle filter. This bioreactor was continuously perfused with substrate and chromogen and AChE activity was analyzed on-line in a flow-through detector. The model has been successfully adopted to Rhesus monkey, swine and guinea pig erythrocytes and intercostal muscle AChE. In addition, the basic kinetic constants of inhibition, aging, spontaneous- and oxime-induced-reactivation of erythrocyte AChE from these species were determined with a standard static model. The major findings were, in part substantial species differences in the inhibition (sarin, paraoxon) and reactivation kinetics (obidoxime, HI 6) of erythrocyte AChE, but comparable kinetics of inhibition and reactivation between erythrocyte and muscle AChE. Hence, these data provide further support of the assumption that erythrocyte AChE is an adequate surrogate of muscle (synaptic) AChE and admonish that major species differences have to be considered for the design and evaluation of therapeutic animal models." @default.
• W2045103418 created "2016-06-24" @default.
• W2045103418 creator A5046465277 @default.
• W2045103418 creator A5057422891 @default.
• W2045103418 creator A5077156605 @default.
• W2045103418 creator A5078195672 @default.
• W2045103418 creator A5079913054 @default.
• W2045103418 date "2010-05-01" @default.
• W2045103418 modified "2023-10-18" @default.
• W2045103418 title "Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon" @default.
• W2045103418 cites W1648076111 @default.
• W2045103418 cites W1964183596 @default.
• W2045103418 cites W1967351568 @default.
• W2045103418 cites W1972892080 @default.
• W2045103418 cites W1975129740 @default.
• W2045103418 cites W1994997596 @default.
• W2045103418 cites W2005765468 @default.
• W2045103418 cites W2024662280 @default.
• W2045103418 cites W2025773423 @default.
• W2045103418 cites W2034947137 @default.
• W2045103418 cites W2038600241 @default.
• W2045103418 cites W2038933848 @default.
• W2045103418 cites W2045314599 @default.
• W2045103418 cites W2060883036 @default.
• W2045103418 cites W2065957780 @default.
• W2045103418 cites W2075870812 @default.
• W2045103418 cites W2079874336 @default.
• W2045103418 cites W2079960443 @default.
• W2045103418 cites W2083258146 @default.
• W2045103418 cites W2087217919 @default.
• W2045103418 cites W2094819493 @default.
• W2045103418 cites W2094922079 @default.
• W2045103418 doi "https://doi.org/10.1016/j.toxlet.2010.02.007" @default.
• W2045103418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20156534" @default.
• W2045103418 hasPublicationYear "2010" @default.
• W2045103418 type Work @default.
• W2045103418 sameAs 2045103418 @default.
• W2045103418 citedByCount "19" @default.
• W2045103418 countsByYear W20451034182012 @default.
• W2045103418 countsByYear W20451034182014 @default.
• W2045103418 countsByYear W20451034182015 @default.
• W2045103418 countsByYear W20451034182016 @default.
• W2045103418 countsByYear W20451034182017 @default.
• W2045103418 countsByYear W20451034182018 @default.
• W2045103418 countsByYear W20451034182020 @default.
• W2045103418 countsByYear W20451034182022 @default.
• W2045103418 countsByYear W20451034182023 @default.
• W2045103418 crossrefType "journal-article" @default.
• W2045103418 hasAuthorship W2045103418A5046465277 @default.
• W2045103418 hasAuthorship W2045103418A5057422891 @default.
• W2045103418 hasAuthorship W2045103418A5077156605 @default.
• W2045103418 hasAuthorship W2045103418A5078195672 @default.
• W2045103418 hasAuthorship W2045103418A5079913054 @default.
• W2045103418 hasConcept C181199279 @default.
• W2045103418 hasConcept C185592680 @default.
• W2045103418 hasConcept C18903297 @default.
• W2045103418 hasConcept C2777207434 @default.
• W2045103418 hasConcept C2777289219 @default.
• W2045103418 hasConcept C2778816929 @default.
• W2045103418 hasConcept C2779059548 @default.
• W2045103418 hasConcept C2779101902 @default.
• W2045103418 hasConcept C2779648554 @default.
• W2045103418 hasConcept C2780292010 @default.
• W2045103418 hasConcept C31896038 @default.
• W2045103418 hasConcept C55493867 @default.
• W2045103418 hasConcept C86803240 @default.
• W2045103418 hasConcept C98274493 @default.
• W2045103418 hasConceptScore W2045103418C181199279 @default.
• W2045103418 hasConceptScore W2045103418C185592680 @default.
• W2045103418 hasConceptScore W2045103418C18903297 @default.
• W2045103418 hasConceptScore W2045103418C2777207434 @default.
• W2045103418 hasConceptScore W2045103418C2777289219 @default.
• W2045103418 hasConceptScore W2045103418C2778816929 @default.
• W2045103418 hasConceptScore W2045103418C2779059548 @default.
• W2045103418 hasConceptScore W2045103418C2779101902 @default.
• W2045103418 hasConceptScore W2045103418C2779648554 @default.
• W2045103418 hasConceptScore W2045103418C2780292010 @default.
• W2045103418 hasConceptScore W2045103418C31896038 @default.
• W2045103418 hasConceptScore W2045103418C55493867 @default.
• W2045103418 hasConceptScore W2045103418C86803240 @default.
• W2045103418 hasConceptScore W2045103418C98274493 @default.
• W2045103418 hasIssue "3" @default.
• W2045103418 hasLocation W20451034181 @default.
• W2045103418 hasLocation W20451034182 @default.
• W2045103418 hasOpenAccess W2045103418 @default.
• W2045103418 hasPrimaryLocation W20451034181 @default.
• W2045103418 hasRelatedWork W1969907774 @default.
• W2045103418 hasRelatedWork W1991586710 @default.
• W2045103418 hasRelatedWork W2089186071 @default.
• W2045103418 hasRelatedWork W2123963850 @default.
• W2045103418 hasRelatedWork W2292999784 @default.
• W2045103418 hasRelatedWork W2356977258 @default.
• W2045103418 hasRelatedWork W2520595390 @default.
• W2045103418 hasRelatedWork W2954278681 @default.
• W2045103418 hasRelatedWork W4360998233 @default.
• W2045103418 hasRelatedWork W169864295 @default.
• W2045103418 hasVolume "194" @default.
• W2045103418 isParatext "false" @default.

• next