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- W2045111937 endingPage "398" @default.
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- W2045111937 abstract "Bioactive proteins signal host or transplanted cells to form the desired tissue type. Matrix systems are utilized to locally deliver the proteins and to maintain effective protein concentrations. For some indications, a matrix is required to define the physical form of the regenerated tissue. Substantial progress has been made in bone tissue engineering in recent years, based on the results of controlled clinical studies using bone morphogenetic proteins. Ongoing research in this area centers on the design of additional delivery matrices to expand the clinical indications, using synthetic delivery systems that mimic biological qualities of the natural materials currently in use. Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial." @default.
- W2045111937 created "2016-06-24" @default.
- W2045111937 creator A5040632685 @default.
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- W2045111937 date "2004-10-01" @default.
- W2045111937 modified "2023-10-03" @default.
- W2045111937 title "Protein-based tissue engineering in bone and cartilage repair" @default.
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- W2045111937 doi "https://doi.org/10.1016/j.copbio.2004.08.001" @default.
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