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• W2045115929 abstract "In Brief Study Design. In vitro studies on the effects of recombinant human growth and differentiation factor-5 (rhGDF-5) on matrix metabolism of bovine intervertebral disc cells and an in vivo study on the effect of rhGDF-5 in the rabbit anular puncture model. Objective. To determine the reparative capacity of rhGDF-5 on the intervertebral disc. Summary of Background Data. The in vitro and in vivo effects of rhGDF-5, a crucial protein in the developing musculoskeletal system, on repair of the degenerated intervertebral disc remain unidentified. Methods. In vitro, bovine nucleus pulposus and anulus fibrosus cells were cultured with or without rhGDF-5 (100 or 200 ng/mL). On days 7, 14, and 21, the contents of deoxyribonucleic acid and proteoglycan, and the synthesis of proteoglycan and collagen were assessed. In vivo, 16 adolescent New Zealand white rabbits received anular punctures in 2 lumbar discs. Four weeks later, phosphate buffered saline or rhGDF-5 (10 ng, 1 and 100 μg) was injected into the nucleus pulposus. The rabbits were followed up for 16 weeks for disc height, magnetic resonance imaging, and histologic grading. Results. In vitro, rhGDF-5 increased the deoxyribonucleic acid and proteoglycan contents of both cell types significantly after day 14. rhGDF-5 at 200 ng/mL significantly stimulated proteoglycan synthesis (nucleus pulposus: +138%, anulus fibrosus: +24%) and collagen synthesis (nucleus pulposus: +95%, anulus fibrosus: +23%) at day 21. In vivo, the injection of rhGDF-5 resulted in a restoration of disc height, improvement of magnetic resonance imaging scores, and histologic grading scores with statistical significance (P < 0.05−0.001). Conclusion. A single injection of rhGDF-5 has a reparative capacity on intervertebral discs, presumably based on its effects to enhance extracellular matrix production in vitro. We have conducted in vitro and in vivo studies to determine the effect of recombinant human growth and differentiation factor (rhGDF)-5 on the intervertebral disc. In vitro, rhGDF-5 enhanced cell proliferation, and matrix synthesis and accumulation by both bovine nucleus pulposus and anulus fibrosus cells cultured in alginate beads. In vivo, a single injection of rhGDF-5 induced restoration of disc height and amelioration of degeneration in both histologic and magnetic resonance imaging findings of the intervertebral discs of rabbit anular puncture model. The results of the 2 studies suggest a therapeutic effect of injecting rhGDF-5 for degenerated intervertebral discs." @default.
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• W2045115929 date "2006-12-01" @default.
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• W2045115929 title "Effects of Growth Differentiation Factor-5 on the Intervertebral Disc−In Vitro Bovine Study and In Vivo Rabbit Disc Degeneration Model Study" @default.
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• W2045115929 doi "https://doi.org/10.1097/01.brs.0000248428.22823.86" @default.
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