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• W2045122511 abstract "The pericardial space may serve as a potential drug delivery reservoir with sustained myocardial delivery and reduced systemic recirculation of therapeutic agents. 1 Laham R.J. Simons M. Tofukuji M. Hung D. Sellke F.W. Modulation of myocardial perfusion and vascular reactivity by pericardial basic fibroblast growth factor insight into ischemia-induced reduction in endothelium-dependent vasodilatation. J Thorac Cardiovasc Surg. 1998; 116: 1022-1028 Abstract Full Text Full Text PDF PubMed Scopus (26) Google Scholar , 2 Laham R.J. Post M. Sellke F.W. Simons M. Therapeutic angiogenesis using local perivascular and pericardial delivery. Curr Interv Cardiol Rep. 2000; 2: 213-217 PubMed Google Scholar , 3 Laham R. Rezaee M. Post M. Novicki D. Sellke F. Pearlman J. Simons M. Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000; 292: 795-802 PubMed Google Scholar , 4 Lazarous D.F. Shou M. Stiber J.A. Dadhania D.M. Thirumurti V. Hodge E. Unger E.F. Pharmacodynamics of basic fibroblast growth factor route of administration determines myocardial and systemic distribution. Cardiovasc Res. 1997; 36: 78-85 Crossref PubMed Scopus (150) Google Scholar “Normal” (without effusion) pericardial access has been achieved by transatrial 5 Waxman S. Pulerwitz T.C. Rowe K.A. Quist W.C. Verrier R.L. Preclinical safety testing of percutaneous transatrial access to the normal pericardial space for local cardiac drug delivery and diagnostic sampling. Catheter Cardiovasc Interv. 2000; 49: 472-477 Crossref PubMed Scopus (33) Google Scholar or subxyphoid access using the PerDUCER device (Cormedicus Inc, Columbia Heights, Minnesota). 6 March K.L. Woody M. Mehdi K. Zipes D.P. Brantly M. Trapnell B.C. Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors. Clin Cardiol. 1999; 22: I23-29 Crossref PubMed Scopus (61) Google Scholar We have recently reported subxyphoid access of the normal pericardium using a blunt-tip needle in animal models for angiogenic drug delivery, demonstrating its safety and efficacy. 3 Laham R. Rezaee M. Post M. Novicki D. Sellke F. Pearlman J. Simons M. Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000; 292: 795-802 PubMed Google Scholar , 7 Laham R. Hung D. Simons M. Subxyphoid access of the normal pericardium a novel drug delivery technique. Cathter Cardiovasc Diagn. 1999; 47: 109-111 Crossref Scopus (34) Google Scholar In addition, although pericardiocentesis is an effective treatment for pericardial effusions, the use of the standard sharp needle, even with echocardiographic guidance, 8 Fagan S.M. Chan K.L. Pericardiocentesis blind no more!. Chest. 1999; 116: 275-276 Crossref PubMed Scopus (24) Google Scholar , 9 Spodick D.H. Intrapericardial therapeutics and diagnostics. Am J Cardiol. 2000; 85: 1012-1014 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar is associated with a low but significant risk of adverse events, including right ventricular puncture and coronary laceration. 8 Fagan S.M. Chan K.L. Pericardiocentesis blind no more!. Chest. 1999; 116: 275-276 Crossref PubMed Scopus (24) Google Scholar , 9 Spodick D.H. Intrapericardial therapeutics and diagnostics. Am J Cardiol. 2000; 85: 1012-1014 Abstract Full Text Full Text PDF PubMed Scopus (13) Google Scholar , 10 Gibbs C.R. Watson R.D. Singh S.P. Lip G.Y. Management of pericardial effusion by drainage a survey of 10 years’ experience in a city centre general hospital serving a multiracial population. Postgrad Med J. 2000; 76: 809-813 Crossref PubMed Scopus (78) Google Scholar Thus, the use of the standard sharp needle technique for pericardial access for drug delivery or epicardial access (for ventricular mapping) is not possible in the absence of pericardial fluid. We report a pilot study of the use of subxyphoid pericardial access using a blunt-tip needle in patients with pericardial effusion as a first step to evaluate feasibility for normal pericardial access." @default.
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• W2045122511 title "Safety of subxyphoid pericardial access using a blunt-tip needle" @default.
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