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• W2045122657 startingPage "4081" @default.
• W2045122657 abstract "Human lactoferrin (hLf) induced an apoptosis-like phenotype in Candida albicans cells, which includes phosphatidylserine externalization, nuclear chromatin condensation, DNA degradation, and increased reactive oxygen species (ROS) production. Intracellular ROS accumulation was seen to correlate with candidacidal activity in hLf-treated cells. Mitochondrial activity was involved as indicated by mitochondrial depolarization and increased hLf resistance of cells preincubated with sordarin or erythromycin, the latter of which inhibits protein synthesis in mitoribosomes. Interestingly, Cl(-)- and K(+)-channel blockers prevented the hLf antimicrobial activity, but only when cells were pretreated with the blocking agent (tetraethylammonium) prior to the hLf-induced K(+)-release period. These results indicate for the first time that K(+)-channel-mediated K(+) efflux is required for the progression of apoptosis-like process in yeast, suggesting that this essential apoptotic event of higher eukaryotes has been evolutionary conserved among species ranging from yeasts to humans." @default.
• W2045122657 created "2016-06-24" @default.
• W2045122657 creator A5025620736 @default.
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• W2045122657 date "2008-11-01" @default.
• W2045122657 modified "2023-10-16" @default.
• W2045122657 title "Human Lactoferrin Induces Apoptosis-Like Cell Death in <i>Candida albicans</i> : Critical Role of K ⁺ -Channel-Mediated K ⁺ Efflux" @default.
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• W2045122657 doi "https://doi.org/10.1128/aac.01597-07" @default.
• W2045122657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2573133" @default.
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• W2045122657 hasPublicationYear "2008" @default.
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