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- W2045128876 abstract "The kinetics of hydrolysis of dextran indomethacin ester conjugates in aqueous buffer solutions in the pH range 6.81–9.13 at 37 ° C was studied. As demonstrated by HPLC, the degradation of the dextran ester derivatives proceeded through parallel formation of 4-chlorobenzoic acid and indomethacin, per se. The pH dependence of the pseudo-first-order rate constants for regeneration of the latter compounds showed parallel straight line portions with slopes close to unity, indicating that the hydrolysis reactions were subject to specific base catalysis. A ratio kOH(Indomethacin)/kOH(4-chlorobenzoic acid) of 3.25 was found, revealing that approximately 25% of the attached indomethacin is degraded while bound to dextran. Compared to the dextran indomethacin ester conjugate, the 2,2,2-trifluoroethyl ester of indomethacin exhibited an almost equal susceptibility towards base-catalyzed hydrolysis. The rate data indicate that the pKa values of the two hydroxy compounds (trifluoroethanol: 12.3 at 25° C) are of comparable size. Thus the results of the kinetic experiments are in favourable agreement with the obtained ionization constant for dextran of 10−11.78 (37 ° C) as determined by potentiometric titration." @default.
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- W2045128876 date "1989-05-01" @default.
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- W2045128876 title "Macromolecular prodrugs. XIII. Determination of the ionization constant of dextran by potentiometric titration and from kinetic analysis of the hydrolysis of dextran indomethacin ester conjugates" @default.
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- W2045128876 doi "https://doi.org/10.1016/0378-5173(89)90088-4" @default.
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