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- W2045129367 abstract "Abstract Since aminoglycosides have been known to exert their antibacterial activities by binding to various RNA targets, 2-deoxystreptamine served as a particularly important model in understanding RNA-small molecule interaction. Herein, 2,4,5-triaminocyclohexanecarboxylic acid was prepared as a novel 2-deoxystreptamine (2-DOS) mimic, which replaces highly flexible glycosidic bonds of aminoglycosides with amide bonds and may improve binding selectivity toward RNA targets through increased rigidity and additional hydrogen-bonding capability. This unnatural g-amino acid can also be used as a potential component for synthetic foldamers." @default.
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- W2045129367 date "2010-03-01" @default.
- W2045129367 modified "2023-09-25" @default.
- W2045129367 title "Synthesis of 2,4,5-triaminocyclohexanecarboxylic acid as a novel 2-deoxystreptamine mimic" @default.
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- W2045129367 doi "https://doi.org/10.1016/j.tetlet.2010.01.111" @default.
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