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• W2045129849 startingPage "14" @default.
• W2045129849 abstract "The dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), plays a key role in dopaminoceptive neurons in the neostriatum (and likely in other brain regions) in signal transduction pathways regulated by a variety of neurotransmitters, neuromodulators, and neuropeptides. Phosphorylation at Thr34 by protein kinase A converts DARPP-32 into a potent inhibitor of the multifunctional serine/threonine protein phosphatase, PP-1. Phosphorylation at Thr75 by Cdk5 converts DARPP-32 into an inhibitor of protein kinase A. The state of phosphorylation of DARPP-32 at Thr34 also depends on the phosphorylation state of Ser102 and Ser137, which are phosphorylated by CK2 and CK1, respectively. By virtue of its regulation of its four phosphorylation sites by a large number of physiological and pharmacological stimuli, and through its ability to modulate the activity of PP-1 and protein kinase A, DARPP-32 plays a key role in integrating a variety of electrophysiological, transcriptional, and behavioral responses. This review focuses on the critical role that DARPP-32 plays in mediating the actions of a broad range of drugs of abuse." @default.
• W2045129849 created "2016-06-24" @default.
• W2045129849 creator A5032456571 @default.
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• W2045129849 creator A5086720984 @default.
• W2045129849 date "2004-01-01" @default.
• W2045129849 modified "2023-10-18" @default.
• W2045129849 title "The role of DARPP-32 in the actions of drugs of abuse" @default.
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• W2045129849 doi "https://doi.org/10.1016/j.neuropharm.2004.05.010" @default.
• W2045129849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15464122" @default.
• W2045129849 hasPublicationYear "2004" @default.
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