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• W2045132324 endingPage "104" @default.
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• W2045132324 abstract "The human corpus luteum (CL) is a highly vascularized, temporarily active endocrine gland and consists mainly of granulosa cells (GCs), theca cells (TCs), and endothelial cells (ECs). Its cyclic growth and development takes place under the influence of gonadotropic hormones. If pregnancy does occur, human chorionic gonadotropin (hCG) takes over the function of luteinizing hormone (LH) and, in contrast to LH, extends the functional life span of the CL. In this study, we investigated the effects of hCG and LH in a spheroidal cell culture model of CL development. Our data indicate that GCs secrete factors under the control of hCG that increase sprout formation of EC-spheroids. We demonstrate that the most prominent of these factors is VEGF-A. Furthermore, we found that both LH and hCG decrease sprout formation of GC-spheroids. After forming EC-GC coculture spheroids and consequently bringing GCs and ECs in close contact, sprouting increased under the influence of hCG, however not under LH. These experiments provide evidence for an hCG dependent functional switch in the GCs after coming in contact with ECs. Moreover, it demonstrates the considerably different effects of hCG and LH on GCs although their signaling is transmitted via the same receptor." @default.
• W2045132324 created "2016-06-24" @default.
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• W2045132324 date "2005-01-01" @default.
• W2045132324 modified "2023-10-17" @default.
• W2045132324 title "Effects of luteinizing hormone and human chorionic gonadotropin on corpus luteum cells in a spheroid cell culture system" @default.
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• W2045132324 doi "https://doi.org/10.1002/mrd.20325" @default.
• W2045132324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15948162" @default.
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