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- W2045134633 abstract "Purpose Data from a recent retrospective analysis (Benza et al, 2011) suggested that higher doses of treprostinil may be associated with better survival in pulmonary arterial hypertension (PAH). Here, we determined whether the dose of treprostinil influences time on therapy and survival of PAH patients in clinical practice. Methods and Materials Retrospective review of all patients in the United States started on intravenous (IV) and subcutaneous (SQ) treprostinil, using data from three specialty pharmacies between September 2009 and October 2011. Deaths from any cause were recorded. Impact of treprostinil dose on the patient’s survival in each month of therapy was analyzed using a Cox proportional hazard model and the ratio was calculated using dose increments of 10 ng/kg/min. Physicians were stratified by experience with parenteral treprostinil (≥5 vs Results 1877 patients (mean age, 51 years) were initiated on parenteral treprostinil. Experienced physicians tended to initiate patients at higher doses and uptitrate more rapidly than less experienced physicians, (P Conclusions Treprostinil dose may influence survival in PAH. More rapid uptitration to a higher dose may be beneficial in these patients. Table 1 Treprostinil Number of patients HR P Value Implications IV+SQ 1877 * 0.992 10 ng/kg/min increase in dose leads to a 7.7% decrease in hazard of death SQ 1032 0.990 0.002 10 ng/kg/min increase in dose leads to a 9.6% decrease in hazard of death IV 837 0.993 0.021 10 ng/kg/min increase in dose leads to a 6.8% decrease in hazard of death * Data pertaining to route of delivery were not available for 8 patients." @default.
- W2045134633 created "2016-06-24" @default.
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- W2045134633 date "2013-04-01" @default.
- W2045134633 modified "2023-10-02" @default.
- W2045134633 title "Impact of Parenteral Treprostinil Dosing in Pulmonary Arterial Hypertension" @default.
- W2045134633 doi "https://doi.org/10.1016/j.healun.2013.01.975" @default.
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