FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045135220> ?p ?o ?g. }

• W2045135220 endingPage "94" @default.
• W2045135220 startingPage "86" @default.
• W2045135220 abstract "Brain-derived neurotrophic factor (BDNF) has been found in the intestinal tract of a variety of species. Its effects on visceral hyperalgesia have been examined to some degree, but limited studies have focused on gut motility. The aim of the present study was to investigate the effects of BDNF on gut motility of mice. Longitudinal muscle (LM) strips were prepared from mice ileum and distal colon. The motility of gut was evaluated by the contraction of LM strips, which was recorded by a polyphisograph in vitro. Firstly, the roles of substance P (SP), calcitonin gene-related peptide (CGRP), and acetylcholine (ACh) on the contraction of LM strips were clarified. Then the exogenous BDNF was administered, and the alterations of SP/CGRP/ACh-induced contractions of the muscle strips were explored. Finally, heterozygous BDNF+/− mice and antibody of TrkB were introduced to investigate the role of endogenous BDNF on the SP/CGRP/ACh-induced gut motility. SP (10− 8–10− 6 mol L− 1), CGRP (10− 8–10− 7 mol L− 1) and ACh (10− 8–10− 6 mol L− 1) dose-dependently caused the contraction of LM strips from ileum and distal colon, while the excitatory effect of CGRP was preceded by a transient inhibition. But 10− 6 mol L− 1 CGRP inhibited the contraction of LM strips. Pretreatment with exogenous BDNF (10− 8 mol L− 1) remarkably enhanced the contraction of LM strips induced by SP (10− 9–10− 7 mol L− 1) and CGRP (10− 8–10− 9 mol L− 1). However, exogenous BDNF couldn't affect the contraction induced by ACh (10− 9–10− 7 mol L− 1). The excitatory effects of SP (10− 8–10− 6 mol L− 1) and CGRP (10− 8–10− 7 mol L− 1) on the contractions of LM strips from ileum and distal colon were significantly attenuated in BDNF+/− mice compared with those in BDNF+/+ mice, while no difference of the effects of ACh (10− 8–10− 6 mol L− 1) on LM strips was observed between BDNF+/− mice and BDNF+/+ mice. The monoclonal antibody of TrkB (TrkB-Ab) dramatically attenuated the excitatory effects of SP and CGRP on the contractions of LM strips, without affecting the excitatory effects of ACh. These data clarified the excitatory effects of SP, ACh and bilateral effects of CGRP on gut motility of mice and confirmed an essential role of BDNF on accelerating gut motility by enhancing the excitatory effects of SP/CGRP." @default.
• W2045135220 created "2016-06-24" @default.
• W2045135220 creator A5008316111 @default.
• W2045135220 creator A5014889491 @default.
• W2045135220 creator A5020530795 @default.
• W2045135220 creator A5036220004 @default.
• W2045135220 creator A5064468525 @default.
• W2045135220 date "2012-10-01" @default.
• W2045135220 modified "2023-10-17" @default.
• W2045135220 title "Brain-derived neurotrophic factor enhances the contraction of intestinal muscle strips induced by SP and CGRP in mice" @default.
• W2045135220 cites W1556133591 @default.
• W2045135220 cites W1625740378 @default.
• W2045135220 cites W1762338891 @default.
• W2045135220 cites W1914763441 @default.
• W2045135220 cites W1922743295 @default.
• W2045135220 cites W1985267787 @default.
• W2045135220 cites W1989034907 @default.
• W2045135220 cites W1999289050 @default.
• W2045135220 cites W1999962515 @default.
• W2045135220 cites W2003159182 @default.
• W2045135220 cites W2013416131 @default.
• W2045135220 cites W2020038557 @default.
• W2045135220 cites W2020560446 @default.
• W2045135220 cites W2024053578 @default.
• W2045135220 cites W2027509638 @default.
• W2045135220 cites W2051675716 @default.
• W2045135220 cites W2056250989 @default.
• W2045135220 cites W2057850960 @default.
• W2045135220 cites W2065766179 @default.
• W2045135220 cites W2066361676 @default.
• W2045135220 cites W2069386587 @default.
• W2045135220 cites W2072142037 @default.
• W2045135220 cites W2074332198 @default.
• W2045135220 cites W2076236727 @default.
• W2045135220 cites W2085235985 @default.
• W2045135220 cites W2092635728 @default.
• W2045135220 cites W2103531658 @default.
• W2045135220 cites W2111438011 @default.
• W2045135220 cites W2129356204 @default.
• W2045135220 cites W2142552497 @default.
• W2045135220 cites W2147082948 @default.
• W2045135220 cites W2152400824 @default.
• W2045135220 cites W2205721999 @default.
• W2045135220 cites W2409473130 @default.
• W2045135220 doi "https://doi.org/10.1016/j.regpep.2012.07.001" @default.
• W2045135220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22800960" @default.
• W2045135220 hasPublicationYear "2012" @default.
• W2045135220 type Work @default.
• W2045135220 sameAs 2045135220 @default.
• W2045135220 citedByCount "36" @default.
• W2045135220 countsByYear W20451352202013 @default.
• W2045135220 countsByYear W20451352202014 @default.
• W2045135220 countsByYear W20451352202015 @default.
• W2045135220 countsByYear W20451352202016 @default.
• W2045135220 countsByYear W20451352202017 @default.
• W2045135220 countsByYear W20451352202018 @default.
• W2045135220 countsByYear W20451352202019 @default.
• W2045135220 countsByYear W20451352202021 @default.
• W2045135220 countsByYear W20451352202022 @default.
• W2045135220 countsByYear W20451352202023 @default.
• W2045135220 crossrefType "journal-article" @default.
• W2045135220 hasAuthorship W2045135220A5008316111 @default.
• W2045135220 hasAuthorship W2045135220A5014889491 @default.
• W2045135220 hasAuthorship W2045135220A5020530795 @default.
• W2045135220 hasAuthorship W2045135220A5036220004 @default.
• W2045135220 hasAuthorship W2045135220A5064468525 @default.
• W2045135220 hasConcept C118303440 @default.
• W2045135220 hasConcept C126322002 @default.
• W2045135220 hasConcept C134018914 @default.
• W2045135220 hasConcept C160539049 @default.
• W2045135220 hasConcept C163170386 @default.
• W2045135220 hasConcept C163415756 @default.
• W2045135220 hasConcept C170493617 @default.
• W2045135220 hasConcept C185592680 @default.
• W2045135220 hasConcept C2775910092 @default.
• W2045135220 hasConcept C2776050358 @default.
• W2045135220 hasConcept C2776533618 @default.
• W2045135220 hasConcept C2777226302 @default.
• W2045135220 hasConcept C2778790584 @default.
• W2045135220 hasConcept C58207958 @default.
• W2045135220 hasConcept C71924100 @default.
• W2045135220 hasConcept C86803240 @default.
• W2045135220 hasConcept C95444343 @default.
• W2045135220 hasConceptScore W2045135220C118303440 @default.
• W2045135220 hasConceptScore W2045135220C126322002 @default.
• W2045135220 hasConceptScore W2045135220C134018914 @default.
• W2045135220 hasConceptScore W2045135220C160539049 @default.
• W2045135220 hasConceptScore W2045135220C163170386 @default.
• W2045135220 hasConceptScore W2045135220C163415756 @default.
• W2045135220 hasConceptScore W2045135220C170493617 @default.
• W2045135220 hasConceptScore W2045135220C185592680 @default.
• W2045135220 hasConceptScore W2045135220C2775910092 @default.
• W2045135220 hasConceptScore W2045135220C2776050358 @default.
• W2045135220 hasConceptScore W2045135220C2776533618 @default.
• W2045135220 hasConceptScore W2045135220C2777226302 @default.
• W2045135220 hasConceptScore W2045135220C2778790584 @default.
• W2045135220 hasConceptScore W2045135220C58207958 @default.
• W2045135220 hasConceptScore W2045135220C71924100 @default.

• next