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- W2045135551 abstract "The introduction of randomised clinical trials of treatment, to research on breast cancer has resulted in a better understanding of the disease and in the use of less radical methods for treating primary tumours. The era really commenced with trials established by Patterson, in Manchester, on radical mastectomy and radiotherapy and on the use of adjuvant oophorectomy. Randomised trails blossomed into the mega studies of the NSABP and CRC in the 1970s and 198Os.‘.’ There are now trials into many aspects of breast disease. Perhaps the three main groups are; (i) the treatment of the primary tumour and I shall largely confine myself to that group, (ii) breast cancer screening and (iii) comparisons of different treatments in advanced disease; also in the word ‘trials’ I shall be referring to the narrower definition of randomised controlled trials. The last 30 years have seen a steady decline in the intensity of local treatment of the primary tumour the standard in the 1950s was radical mastectomy followed by radiotherapy; now simple mastectomy or treatment with breast conservation, without radical attack on the lymph nodes. These changes followed a series of clinical trials but the questions are would the changes have occurred anyway and are the treatments found to be best in the trials applicable to all patients?" @default.
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- W2045135551 title "Randomised clinical trials in breast cancer" @default.
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- W2045135551 doi "https://doi.org/10.1016/0960-9776(92)90128-o" @default.
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