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• W2045137071 abstract "Cannabinoid receptors, CB1 and CB2, are therapeutic targets in the treatment of anxiety, obesity, movement disorders, glaucoma, and pain. We have developed an on-line screening method for CB1 and CB2 ligands, where cellular membrane fragments of a chronic myelogenous leukemia cell line, KU-812, were immobilized onto the surface of an open tubular (OT) capillary to create a CB1/CB2–OT column. The binding activities of the immobilized CB1/CB2 receptors were established using frontal affinity chromatographic techniques. This is the first report that confirms the presence of functional CB1 and CB2 receptors on KU-812 cells. The data from this study confirm that the CB1/CB2–OT column can be used to determine the binding affinities (Ki values) for a single compound and to screen individual compounds or a mixture of multiple compounds. The CB1/CB2–OT column was also used to screen a botanical matrix, Zanthoxylum clava-herculis, where preliminary results suggest the presence of a high-affinity phytocannabinoid." @default.
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• W2045137071 date "2011-05-01" @default.
• W2045137071 modified "2023-10-01" @default.
• W2045137071 title "Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening" @default.
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• W2045137071 doi "https://doi.org/10.1016/j.ab.2010.12.034" @default.
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