Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045137797> ?p ?o ?g. }
- W2045137797 endingPage "286" @default.
- W2045137797 startingPage "275" @default.
- W2045137797 abstract "‘Toxicogenomics’, the use of complex populations of mRNA to understand toxicity, is a relatively new field which combines the wealth of gene sequence information with advances in miniaturisation technology. In a parallel evolutionary path that the broader field of toxicology has encountered, toxicogenomics is steadily changing from descriptive to mechanistic research and will ultimately progress to a predictive science. This review focuses on the application of microarray research tools to toxicology studies in preclinical development. In particular, the ‘testing funnel’ approach to candidate selection in drug development is used to discuss the strategic implementation of toxicogenomics to help develop drugs that harbour less toxicity. Examples of where toxicogenomics has increased mechanistic and descriptive understanding of cellular toxicity are discussed, as are early efforts to develop molecular biomarkers that are predictive of longer-term toxicity." @default.
- W2045137797 created "2016-06-24" @default.
- W2045137797 creator A5007249360 @default.
- W2045137797 creator A5077350810 @default.
- W2045137797 date "2002-09-01" @default.
- W2045137797 modified "2023-10-09" @default.
- W2045137797 title "Toxicogenomics: an opportunity to optimise drug development and safety evaluation" @default.
- W2045137797 cites W1503337666 @default.
- W2045137797 cites W1544923801 @default.
- W2045137797 cites W1949238489 @default.
- W2045137797 cites W1974988750 @default.
- W2045137797 cites W1981788436 @default.
- W2045137797 cites W1982290436 @default.
- W2045137797 cites W1984080722 @default.
- W2045137797 cites W199981973 @default.
- W2045137797 cites W1999858228 @default.
- W2045137797 cites W2004352153 @default.
- W2045137797 cites W2013997066 @default.
- W2045137797 cites W2019781881 @default.
- W2045137797 cites W2021551481 @default.
- W2045137797 cites W2025191426 @default.
- W2045137797 cites W2026714659 @default.
- W2045137797 cites W2031838201 @default.
- W2045137797 cites W2036094388 @default.
- W2045137797 cites W2043981588 @default.
- W2045137797 cites W2044112975 @default.
- W2045137797 cites W2045078909 @default.
- W2045137797 cites W2046325363 @default.
- W2045137797 cites W2053365325 @default.
- W2045137797 cites W2066164282 @default.
- W2045137797 cites W2066748372 @default.
- W2045137797 cites W2072794124 @default.
- W2045137797 cites W2091907178 @default.
- W2045137797 cites W2095018624 @default.
- W2045137797 cites W2098132781 @default.
- W2045137797 cites W2101804080 @default.
- W2045137797 cites W2103697108 @default.
- W2045137797 cites W2104209550 @default.
- W2045137797 cites W2104688517 @default.
- W2045137797 cites W2124259172 @default.
- W2045137797 cites W2127230663 @default.
- W2045137797 cites W2128985829 @default.
- W2045137797 cites W2132142759 @default.
- W2045137797 cites W2133036086 @default.
- W2045137797 cites W2140535485 @default.
- W2045137797 cites W2141341794 @default.
- W2045137797 cites W2149720473 @default.
- W2045137797 cites W2159436855 @default.
- W2045137797 cites W2168284337 @default.
- W2045137797 cites W2170106455 @default.
- W2045137797 cites W4233232270 @default.
- W2045137797 cites W4240123587 @default.
- W2045137797 doi "https://doi.org/10.1517/14740338.1.3.275" @default.
- W2045137797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12904143" @default.
- W2045137797 hasPublicationYear "2002" @default.
- W2045137797 type Work @default.
- W2045137797 sameAs 2045137797 @default.
- W2045137797 citedByCount "24" @default.
- W2045137797 countsByYear W20451377972013 @default.
- W2045137797 countsByYear W20451377972014 @default.
- W2045137797 countsByYear W20451377972019 @default.
- W2045137797 countsByYear W20451377972020 @default.
- W2045137797 crossrefType "journal-article" @default.
- W2045137797 hasAuthorship W2045137797A5007249360 @default.
- W2045137797 hasAuthorship W2045137797A5077350810 @default.
- W2045137797 hasConcept C104317684 @default.
- W2045137797 hasConcept C112930515 @default.
- W2045137797 hasConcept C150194340 @default.
- W2045137797 hasConcept C202444582 @default.
- W2045137797 hasConcept C2522767166 @default.
- W2045137797 hasConcept C2780035454 @default.
- W2045137797 hasConcept C2992092908 @default.
- W2045137797 hasConcept C33070731 @default.
- W2045137797 hasConcept C33923547 @default.
- W2045137797 hasConcept C41008148 @default.
- W2045137797 hasConcept C54355233 @default.
- W2045137797 hasConcept C60644358 @default.
- W2045137797 hasConcept C64903051 @default.
- W2045137797 hasConcept C70721500 @default.
- W2045137797 hasConcept C71924100 @default.
- W2045137797 hasConcept C74187038 @default.
- W2045137797 hasConcept C86803240 @default.
- W2045137797 hasConcept C93231420 @default.
- W2045137797 hasConcept C9652623 @default.
- W2045137797 hasConcept C98274493 @default.
- W2045137797 hasConceptScore W2045137797C104317684 @default.
- W2045137797 hasConceptScore W2045137797C112930515 @default.
- W2045137797 hasConceptScore W2045137797C150194340 @default.
- W2045137797 hasConceptScore W2045137797C202444582 @default.
- W2045137797 hasConceptScore W2045137797C2522767166 @default.
- W2045137797 hasConceptScore W2045137797C2780035454 @default.
- W2045137797 hasConceptScore W2045137797C2992092908 @default.
- W2045137797 hasConceptScore W2045137797C33070731 @default.
- W2045137797 hasConceptScore W2045137797C33923547 @default.
- W2045137797 hasConceptScore W2045137797C41008148 @default.
- W2045137797 hasConceptScore W2045137797C54355233 @default.
- W2045137797 hasConceptScore W2045137797C60644358 @default.
- W2045137797 hasConceptScore W2045137797C64903051 @default.