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- W2045138802 abstract "Abstract G protein-coupled signaling systems are the most important targets for therapeutic drugs, most of which are ligands for heptahelical receptors (7TM-R). A single receptor can activate various signaling pathways in different cells; consequently, drugs that target the receptor binding site are not necessarily specific for particular pathways. However, other downstream signaling partners that interact with heptahelical receptors can be unique for a given pathway and peptide motifs that are involved in these interactions are potential targets for the development of drugs with greater specificity and fewer side effects. Furthermore, it is becoming apparent that these systems are organized as protein complexes, making proteomic techniques ideal tools for identifying system components." @default.
- W2045138802 created "2016-06-24" @default.
- W2045138802 creator A5021824403 @default.
- W2045138802 creator A5031216810 @default.
- W2045138802 creator A5052328017 @default.
- W2045138802 date "2004-06-01" @default.
- W2045138802 modified "2023-09-26" @default.
- W2045138802 title "The targetable G protein proteome: where is the next generation of drug targets?" @default.
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- W2045138802 doi "https://doi.org/10.1016/s1741-8372(04)02429-6" @default.
- W2045138802 hasPublicationYear "2004" @default.
- W2045138802 type Work @default.