Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045156352> ?p ?o ?g. }
- W2045156352 endingPage "1657" @default.
- W2045156352 startingPage "1648" @default.
- W2045156352 abstract "Although the etiology of intervertebral disc degeneration is poorly understood, one possible approach for its regulation is apoptosis inhibition. This study was undertaken to investigate the antiapoptotic effects of caspase 3 in intervertebral disc degeneration in rabbits.We investigated the effects of caspase 3 small interfering RNA (siRNA) on rabbit nucleus pulposus cells in a serum-starved medium. The effects of direct injection of Alexa Fluor 555-labeled caspase 3 siRNA into the intervertebral disc were also determined in vivo using the rabbit anular needle puncture model.Rabbit nucleus pulposus cells transfected with caspase 3 siRNA showed a significant decrease in serum-starved apoptotic cells. After local injection of caspase 3 siRNA into intervertebral discs, red fluorescence was observed in the nucleus pulposus upon treatment with Alexa Fluor 555-labeled caspase 3 siRNA. Caspase 3 messenger RNA and protein were down-regulated in the caspase 3 siRNA group. Magnetic resonance imaging and histologic evaluation showed that degenerative changes were significantly suppressed in the caspase 3 siRNA group 4 and 8 weeks after injection. Quantification of TUNEL staining showed that the caspase 3 siRNA group had significantly fewer apoptotic nucleus pulposus cells than the control siRNA group.Our findings indicate that caspase 3 knockdown in rabbit intervertebral disc cells is effective in preventing apoptotic cell death, thus regulating intervertebral disc degeneration." @default.
- W2045156352 created "2016-06-24" @default.
- W2045156352 creator A5021932087 @default.
- W2045156352 creator A5068425868 @default.
- W2045156352 date "2011-05-31" @default.
- W2045156352 modified "2023-10-15" @default.
- W2045156352 title "Caspase 3 as a therapeutic target for regulation of intervertebral disc degeneration in rabbits" @default.
- W2045156352 cites W143623202 @default.
- W2045156352 cites W1481188702 @default.
- W2045156352 cites W1533220576 @default.
- W2045156352 cites W1581461985 @default.
- W2045156352 cites W1966188170 @default.
- W2045156352 cites W1967912613 @default.
- W2045156352 cites W1970734303 @default.
- W2045156352 cites W1971036564 @default.
- W2045156352 cites W1973721469 @default.
- W2045156352 cites W1994834259 @default.
- W2045156352 cites W1996888339 @default.
- W2045156352 cites W2006803278 @default.
- W2045156352 cites W2012547585 @default.
- W2045156352 cites W2016565658 @default.
- W2045156352 cites W2021449823 @default.
- W2045156352 cites W2026275453 @default.
- W2045156352 cites W2029593537 @default.
- W2045156352 cites W2041191443 @default.
- W2045156352 cites W2045115929 @default.
- W2045156352 cites W2045770273 @default.
- W2045156352 cites W2053245387 @default.
- W2045156352 cites W2062268866 @default.
- W2045156352 cites W2065011645 @default.
- W2045156352 cites W2067909000 @default.
- W2045156352 cites W2078532650 @default.
- W2045156352 cites W2087600424 @default.
- W2045156352 cites W2099468814 @default.
- W2045156352 cites W2113961735 @default.
- W2045156352 cites W2130841232 @default.
- W2045156352 cites W2133298632 @default.
- W2045156352 cites W2139098448 @default.
- W2045156352 cites W2146888510 @default.
- W2045156352 cites W2151501496 @default.
- W2045156352 cites W2156670502 @default.
- W2045156352 cites W2161134772 @default.
- W2045156352 cites W2323837976 @default.
- W2045156352 cites W2406721410 @default.
- W2045156352 cites W27072853 @default.
- W2045156352 doi "https://doi.org/10.1002/art.30251" @default.
- W2045156352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21305515" @default.
- W2045156352 hasPublicationYear "2011" @default.
- W2045156352 type Work @default.
- W2045156352 sameAs 2045156352 @default.
- W2045156352 citedByCount "81" @default.
- W2045156352 countsByYear W20451563522012 @default.
- W2045156352 countsByYear W20451563522013 @default.
- W2045156352 countsByYear W20451563522014 @default.
- W2045156352 countsByYear W20451563522015 @default.
- W2045156352 countsByYear W20451563522016 @default.
- W2045156352 countsByYear W20451563522017 @default.
- W2045156352 countsByYear W20451563522018 @default.
- W2045156352 countsByYear W20451563522019 @default.
- W2045156352 countsByYear W20451563522020 @default.
- W2045156352 countsByYear W20451563522021 @default.
- W2045156352 countsByYear W20451563522022 @default.
- W2045156352 countsByYear W20451563522023 @default.
- W2045156352 crossrefType "journal-article" @default.
- W2045156352 hasAuthorship W2045156352A5021932087 @default.
- W2045156352 hasAuthorship W2045156352A5068425868 @default.
- W2045156352 hasBestOaLocation W20451563521 @default.
- W2045156352 hasConcept C105702510 @default.
- W2045156352 hasConcept C12519072 @default.
- W2045156352 hasConcept C142724271 @default.
- W2045156352 hasConcept C153911025 @default.
- W2045156352 hasConcept C173396325 @default.
- W2045156352 hasConcept C185592680 @default.
- W2045156352 hasConcept C190283241 @default.
- W2045156352 hasConcept C196795494 @default.
- W2045156352 hasConcept C22615655 @default.
- W2045156352 hasConcept C2777755357 @default.
- W2045156352 hasConcept C31573885 @default.
- W2045156352 hasConcept C54009773 @default.
- W2045156352 hasConcept C54355233 @default.
- W2045156352 hasConcept C55493867 @default.
- W2045156352 hasConcept C71924100 @default.
- W2045156352 hasConcept C81885089 @default.
- W2045156352 hasConcept C86803240 @default.
- W2045156352 hasConcept C95444343 @default.
- W2045156352 hasConcept C98424977 @default.
- W2045156352 hasConceptScore W2045156352C105702510 @default.
- W2045156352 hasConceptScore W2045156352C12519072 @default.
- W2045156352 hasConceptScore W2045156352C142724271 @default.
- W2045156352 hasConceptScore W2045156352C153911025 @default.
- W2045156352 hasConceptScore W2045156352C173396325 @default.
- W2045156352 hasConceptScore W2045156352C185592680 @default.
- W2045156352 hasConceptScore W2045156352C190283241 @default.
- W2045156352 hasConceptScore W2045156352C196795494 @default.
- W2045156352 hasConceptScore W2045156352C22615655 @default.
- W2045156352 hasConceptScore W2045156352C2777755357 @default.
- W2045156352 hasConceptScore W2045156352C31573885 @default.
- W2045156352 hasConceptScore W2045156352C54009773 @default.