FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045157045> ?p ?o ?g. }

• W2045157045 endingPage "408" @default.
• W2045157045 startingPage "394" @default.
• W2045157045 abstract "The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental and inflammatory stimulus-inducible genes in macrophages, but the mechanisms underlying these two different functions are largely unknown. One possibility is that these different roles are linked to the ability of IRF8 to bind alternative DNA sequences. We found that IRF8 is recruited to distinct sets of DNA consensus sequences before and after lipopolysaccharide (LPS) stimulation. In resting cells, IRF8 was mainly bound to composite sites together with the master regulator of myeloid development PU.1. Basal IRF8–PU.1 binding maintained the expression of a broad panel of genes essential for macrophage functions (such as microbial recognition and response to purines) and contributed to basal expression of many LPS-inducible genes. After LPS stimulation, increased expression of IRF8, other IRFs, and AP-1 family TFs enabled IRF8 binding to thousands of additional regions containing low-affinity multimerized IRF sites and composite IRF–AP-1 sites, which were not premarked by PU.1 and did not contribute to the basal IRF8 cistrome. While constitutively expressed IRF8-dependent genes contained only sites mediating basal IRF8/PU.1 recruitment, inducible IRF8-dependent genes contained variable combinations of constitutive and inducible sites. Overall, these data show at the genome scale how the same TF can be linked to constitutive and inducible gene regulation via distinct combinations of alternative DNA-binding sites." @default.
• W2045157045 created "2016-06-24" @default.
• W2045157045 creator A5016215574 @default.
• W2045157045 creator A5033861845 @default.
• W2045157045 creator A5045764730 @default.
• W2045157045 creator A5058763661 @default.
• W2045157045 creator A5061381922 @default.
• W2045157045 creator A5071298334 @default.
• W2045157045 creator A5080587435 @default.
• W2045157045 date "2015-01-30" @default.
• W2045157045 modified "2023-10-14" @default.
• W2045157045 title "A dual <i>cis</i>-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages" @default.
• W2045157045 cites W1917240678 @default.
• W2045157045 cites W1965064177 @default.
• W2045157045 cites W1966282784 @default.
• W2045157045 cites W1968458512 @default.
• W2045157045 cites W1979594866 @default.
• W2045157045 cites W1980779363 @default.
• W2045157045 cites W1980860344 @default.
• W2045157045 cites W1982754708 @default.
• W2045157045 cites W1982857307 @default.
• W2045157045 cites W1991608694 @default.
• W2045157045 cites W1995841566 @default.
• W2045157045 cites W1998871958 @default.
• W2045157045 cites W2000177767 @default.
• W2045157045 cites W2001042507 @default.
• W2045157045 cites W2004017460 @default.
• W2045157045 cites W2004662779 @default.
• W2045157045 cites W2006368636 @default.
• W2045157045 cites W2014677321 @default.
• W2045157045 cites W2015415445 @default.
• W2045157045 cites W2018724286 @default.
• W2045157045 cites W2022328060 @default.
• W2045157045 cites W2023323030 @default.
• W2045157045 cites W2026690931 @default.
• W2045157045 cites W2032197035 @default.
• W2045157045 cites W2038239151 @default.
• W2045157045 cites W2045067923 @default.
• W2045157045 cites W2045510187 @default.
• W2045157045 cites W2063194386 @default.
• W2045157045 cites W2065391646 @default.
• W2045157045 cites W2083385452 @default.
• W2045157045 cites W2094504570 @default.
• W2045157045 cites W2100305481 @default.
• W2045157045 cites W2106301141 @default.
• W2045157045 cites W2107922733 @default.
• W2045157045 cites W2108399976 @default.
• W2045157045 cites W2108834755 @default.
• W2045157045 cites W2113933754 @default.
• W2045157045 cites W2119318931 @default.
• W2045157045 cites W2119479037 @default.
• W2045157045 cites W2123564569 @default.
• W2045157045 cites W2126811287 @default.
• W2045157045 cites W2128557245 @default.
• W2045157045 cites W2129613765 @default.
• W2045157045 cites W2129937975 @default.
• W2045157045 cites W2135018484 @default.
• W2045157045 cites W2139683904 @default.
• W2045157045 cites W2147640266 @default.
• W2045157045 cites W2153570621 @default.
• W2045157045 cites W2163774748 @default.
• W2045157045 cites W2167218320 @default.
• W2045157045 cites W2170621724 @default.
• W2045157045 cites W2275237548 @default.
• W2045157045 cites W2333195534 @default.
• W2045157045 cites W4210347168 @default.
• W2045157045 cites W4239510810 @default.
• W2045157045 doi "https://doi.org/10.1101/gad.257592.114" @default.
• W2045157045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4335295" @default.
• W2045157045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25637355" @default.
• W2045157045 hasPublicationYear "2015" @default.
• W2045157045 type Work @default.
• W2045157045 sameAs 2045157045 @default.
• W2045157045 citedByCount "95" @default.
• W2045157045 countsByYear W20451570452015 @default.
• W2045157045 countsByYear W20451570452016 @default.
• W2045157045 countsByYear W20451570452017 @default.
• W2045157045 countsByYear W20451570452018 @default.
• W2045157045 countsByYear W20451570452019 @default.
• W2045157045 countsByYear W20451570452020 @default.
• W2045157045 countsByYear W20451570452021 @default.
• W2045157045 countsByYear W20451570452022 @default.
• W2045157045 countsByYear W20451570452023 @default.
• W2045157045 crossrefType "journal-article" @default.
• W2045157045 hasAuthorship W2045157045A5016215574 @default.
• W2045157045 hasAuthorship W2045157045A5033861845 @default.
• W2045157045 hasAuthorship W2045157045A5045764730 @default.
• W2045157045 hasAuthorship W2045157045A5058763661 @default.
• W2045157045 hasAuthorship W2045157045A5061381922 @default.
• W2045157045 hasAuthorship W2045157045A5071298334 @default.
• W2045157045 hasAuthorship W2045157045A5080587435 @default.
• W2045157045 hasBestOaLocation W20451570451 @default.
• W2045157045 hasConcept C104317684 @default.
• W2045157045 hasConcept C117705580 @default.
• W2045157045 hasConcept C150194340 @default.
• W2045157045 hasConcept C165864922 @default.
• W2045157045 hasConcept C21592294 @default.
• W2045157045 hasConcept C54355233 @default.

• next