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• W2045160187 endingPage "54" @default.
• W2045160187 startingPage "47" @default.
• W2045160187 abstract "The fragile-X mental retardation protein (FMRP) is greatly reduced or absent in individuals with fragile-X mental retardation syndrome, a common, heritable form of mental retardation. Morphological studies suggest that this protein functions in normal synapse maturation and neuronal plasticity. Examination of human brain autopsy tissue has shown that fragile-X patients exhibit long, thin spines more frequently, and stubby mushroom-shaped spines less frequently, than these two types of spines are seen in normal autopsy tissue. Fragile-X tissue also has a greater density of these spines along dendrites, which suggests a possible failure of synapse elimination. Fmr1 knockout mice and wild-type littermates brains were processed for Timm staining, which reveals the zinc-rich terminals of the dentate gyrus, the mossy fibers. The Fmr1 knockout mice exhibited a pattern of Timm granule-staining within the stratum oriens of subfield CA3 and the inner molecular layer that was significantly different than staining seen in wild-type animals. The sources and consequences of the altered terminal staining are unclear, but are discussed in relation to immature synapse morphology, a failure of normal regression of synapses, and a potential biological penalty of such a failure to regress." @default.
• W2045160187 created "2016-06-24" @default.
• W2045160187 creator A5067148691 @default.
• W2045160187 creator A5085647019 @default.
• W2045160187 date "2002-01-01" @default.
• W2045160187 modified "2023-10-18" @default.
• W2045160187 title "Altered mossy fiber distributions in adultFmr1 (FVB) knockout mice" @default.
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• W2045160187 doi "https://doi.org/10.1002/hipo.10004" @default.
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