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- W2045161488 abstract "During oxidative cardiac metabolism, the myocardium produces reactive oxygen species, such as superoxide and hydrogen peroxide (H(2)O(2)). We hypothesized H(2)O(2) is a coronary metabolic dilator linking regulation of coronary tone with myocardium metabolism. Dilation of isolated, pressurized coronary arterioles (76 +/- 10 microm, diameter) in reaction to supernatant collected from enzymatically isolated cardiac myocytes was measured. Isolated rat myocytes were stimulated electrically [unpaced or stimulated at 200, 400 beats/min (bpm)]. H(2)O(2) was significantly generated by pacing (400 bpm n = 11, 9.3 +/- 0.4 microM P < 0.01, versus unpaced) and the addition of this supernatant caused vasodilation (500 microL to 2 mL bath, 14.6 +/- 0.7%, P < 0.01 versus unpaced). Supernatant from unpaced myocytes was not vasoactive. To clarify the source of H(2)O(2), myocytes were also stimulated at 400 bpm following treatment with Mn-TBAP (25 microM), which mimics the action of Mn-SOD, and apocynin (3 mM), an NADPH oxidase inhibitor (n = 11, each). Mn-TBAP increased H(2)O(2) generation in myocyte supernatant stimulated at 400 bpm (12.2 +/- 0.8 microM, P < 0.01 versus 400 bpm stimulation only). Treatment of the myocytes with Mn-TBAP augmented vasodilation by the stimulated myocyte supernatant (19.6 +/- 1.1%, P < 0.01 versus untreated myocyte supernatant). Apocynin did not alter vasodilation to myocyte supernatant. These results suggest that the main source of superoxide by metabolic stimuli is cardiac myocytes and Mn-SOD is a scavenger from superoxide to H(2)O(2). We conclude that H(2)O(2) is a key metabolic vasodilator produced by myocardium." @default.
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- W2045161488 date "2010-01-01" @default.
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- W2045161488 title "Hydrogen Peroxide Generated From Cardiac Myocytes Impacts Metabolic Dilation in Coronary Arterioles" @default.
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- W2045161488 doi "https://doi.org/10.1536/ihj.51.125" @default.
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