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- W2045162550 abstract "The present study investigated the modulatory actions of nociceptin/orphanin FQ on excitatory glutamatergic transmission in spinal dorsal horn. In transverse spinal cord slices with an attached dorsal root, mono- and polysynaptic Aδ-fibre-evoked extracellular field potentials were recorded from superficial dorsal horn. Nociceptin/orphanin FQ showed bidirectional effects on monosynaptic transmission with a potentiation at lower concentrations (100–300 nM) and a dose-dependent depression at higher concentrations (1–3 μM). The polysynaptic field potential was dose-dependently depressed by nociceptin/orphanin FQ (100 nM–3 μM). None of the actions of nociceptin/orphanin FQ was reversed by the non-specific opioid receptor antagonist naloxone, the N-methyl-D-aspartate receptor antagonist D-2-amino-5-phosphonovaleric acid or the peptide nocistatin. The bidirectional actions of nociceptin/orphanin FQ on the monosynaptic field potential may provide an in vitro model for the bidirectional actions of nociceptin/orphanin FQ in behavioural studies showing hyperalgesia at low doses of intrathecal nociceptin/orphanin FQ and analgesia at higher doses." @default.
- W2045162550 created "2016-06-24" @default.
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- W2045162550 date "2001-11-01" @default.
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- W2045162550 title "Bidirectional actions of nociceptin/orphanin FQ on Aδ-fibre-evoked responses in rat superficial spinal dorsal horn in vitro" @default.
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- W2045162550 doi "https://doi.org/10.1016/s0306-4522(01)00354-2" @default.
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