FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045164548> ?p ?o ?g. }

• W2045164548 endingPage "1434" @default.
• W2045164548 startingPage "1425" @default.
• W2045164548 abstract "Abstract The hippocampus is a brain region critical for learning and memory processes believed to result from long‐lasting changes in the function and structure of synapses. Recent findings suggest that ATP functions as a neurotransmitter or neuromodulator in the mammalian brain, where it activates several different types of ionotropic and G protein‐coupled ATP receptors that transduce calcium signals. However, the roles of specific ATP receptors in synaptic plasticity have not been established. Here we show that mice lacking the P2X3 ATP receptor (P2X3KO mice) exhibit abnormalities in hippocampal synaptic plasticity that can be restored by pharmacological modification of calcium‐sensitive kinase and phosphatase activities. Calcium imaging studies revealed an attenuated calcium response to ATP in hippocampal neurons from P2X3KO mice. Basal synaptic transmission, paired‐pulse facilitation and long‐term potentiation are normal at synapses in hippocampal slices from P2X3KO. However, long‐term depression is severely impaired at CA1, CA3 and dentate gyrus synapses. Long‐term depression can be partially rescued in slices treated with a protein phosphatase 1–2 A activator or by postsynaptic inhibition of calcium/calmodulin‐dependent protein kinase II. Despite the deficit in hippocampal long‐term depression, P2X3KO mice performed normally in water maze tests of spatial learning, suggesting that long‐term depression is not critical for this type of hippocampus‐dependent learning and memory." @default.
• W2045164548 created "2016-06-24" @default.
• W2045164548 creator A5022491794 @default.
• W2045164548 creator A5023418172 @default.
• W2045164548 creator A5033632697 @default.
• W2045164548 creator A5040769857 @default.
• W2045164548 creator A5044264789 @default.
• W2045164548 creator A5047776373 @default.
• W2045164548 creator A5068354292 @default.
• W2045164548 creator A5081545917 @default.
• W2045164548 creator A5083040475 @default.
• W2045164548 date "2006-08-22" @default.
• W2045164548 modified "2023-10-16" @default.
• W2045164548 title "Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit" @default.
• W2045164548 cites W1485797978 @default.
• W2045164548 cites W1507242444 @default.
• W2045164548 cites W1596522411 @default.
• W2045164548 cites W1599213556 @default.
• W2045164548 cites W1623121663 @default.
• W2045164548 cites W1964157347 @default.
• W2045164548 cites W1965650841 @default.
• W2045164548 cites W1973257702 @default.
• W2045164548 cites W1974260260 @default.
• W2045164548 cites W1985405412 @default.
• W2045164548 cites W1987660775 @default.
• W2045164548 cites W1988601231 @default.
• W2045164548 cites W2000705375 @default.
• W2045164548 cites W2002108194 @default.
• W2045164548 cites W2015901486 @default.
• W2045164548 cites W2015983970 @default.
• W2045164548 cites W2017842551 @default.
• W2045164548 cites W2021852616 @default.
• W2045164548 cites W2022581358 @default.
• W2045164548 cites W2025150024 @default.
• W2045164548 cites W2030131218 @default.
• W2045164548 cites W2039247483 @default.
• W2045164548 cites W2040600808 @default.
• W2045164548 cites W2045125289 @default.
• W2045164548 cites W2047591680 @default.
• W2045164548 cites W2048877266 @default.
• W2045164548 cites W2050016412 @default.
• W2045164548 cites W2052841880 @default.
• W2045164548 cites W2056027814 @default.
• W2045164548 cites W2085112484 @default.
• W2045164548 cites W2089715790 @default.
• W2045164548 cites W2095625208 @default.
• W2045164548 cites W2096789499 @default.
• W2045164548 cites W2102256305 @default.
• W2045164548 cites W2122357222 @default.
• W2045164548 cites W2148863076 @default.
• W2045164548 cites W2167923782 @default.
• W2045164548 cites W2172228212 @default.
• W2045164548 cites W2234527206 @default.
• W2045164548 doi "https://doi.org/10.1111/j.1471-4159.2006.04198.x" @default.
• W2045164548 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17074061" @default.
• W2045164548 hasPublicationYear "2006" @default.
• W2045164548 type Work @default.
• W2045164548 sameAs 2045164548 @default.
• W2045164548 citedByCount "21" @default.
• W2045164548 countsByYear W20451645482012 @default.
• W2045164548 countsByYear W20451645482016 @default.
• W2045164548 countsByYear W20451645482017 @default.
• W2045164548 countsByYear W20451645482018 @default.
• W2045164548 countsByYear W20451645482020 @default.
• W2045164548 countsByYear W20451645482021 @default.
• W2045164548 crossrefType "journal-article" @default.
• W2045164548 hasAuthorship W2045164548A5022491794 @default.
• W2045164548 hasAuthorship W2045164548A5023418172 @default.
• W2045164548 hasAuthorship W2045164548A5033632697 @default.
• W2045164548 hasAuthorship W2045164548A5040769857 @default.
• W2045164548 hasAuthorship W2045164548A5044264789 @default.
• W2045164548 hasAuthorship W2045164548A5047776373 @default.
• W2045164548 hasAuthorship W2045164548A5068354292 @default.
• W2045164548 hasAuthorship W2045164548A5081545917 @default.
• W2045164548 hasAuthorship W2045164548A5083040475 @default.
• W2045164548 hasBestOaLocation W20451645481 @default.
• W2045164548 hasConcept C115955781 @default.
• W2045164548 hasConcept C126322002 @default.
• W2045164548 hasConcept C134018914 @default.
• W2045164548 hasConcept C148762608 @default.
• W2045164548 hasConcept C160268369 @default.
• W2045164548 hasConcept C169760540 @default.
• W2045164548 hasConcept C170493617 @default.
• W2045164548 hasConcept C185592680 @default.
• W2045164548 hasConcept C200170125 @default.
• W2045164548 hasConcept C25274449 @default.
• W2045164548 hasConcept C2776464000 @default.
• W2045164548 hasConcept C2781161787 @default.
• W2045164548 hasConcept C55493867 @default.
• W2045164548 hasConcept C67018056 @default.
• W2045164548 hasConcept C71924100 @default.
• W2045164548 hasConcept C73009533 @default.
• W2045164548 hasConcept C86803240 @default.
• W2045164548 hasConcept C98229152 @default.
• W2045164548 hasConceptScore W2045164548C115955781 @default.
• W2045164548 hasConceptScore W2045164548C126322002 @default.
• W2045164548 hasConceptScore W2045164548C134018914 @default.
• W2045164548 hasConceptScore W2045164548C148762608 @default.

• next