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• W2045168631 endingPage "185" @default.
• W2045168631 startingPage "177" @default.
• W2045168631 abstract "The human cytomegalovirus UL18 protein, an MHC class I homologue, has been shown to bind to leucocyte immunoglobulin-like receptor (LIR)-1, a member of a family of nine closely related immunoglobulin superfamily receptors expressed on leucocytes. The LIRs are related to the natural killer (NK)-cell immunoglobulin-like receptors and to several other immunoreceptors. Three groups of LIR molecules have been defined: those containing cytoplasmic domain inhibitory signalling motifs, those with short cytoplasmic domains and a charged residue within the transmembrane domain, and a secreted molecule. LIR-1 and LIR-2 bind to a broad spectrum of cellular MHC class I antigens, including HLA-A, -B and -C alleles. LIR-2 is expressed by all monocytes and dendritic cells, whereas LIR-1 is additionally expressed by B cells and subsets of T and NK cells. Upon tyrosine phosphorylation, LIR-1 and LIR-2 associate with the tyrosine phosphatase, SHP-1, and have been shown to inhibit Fc gamma RI signalling when co-crosslinked in monocytes. Evidence for and against a role of UL18 as an inhibitor of NK-cell function is discussed, as are possible functional outcomes of UL18-LIR-1 interactions in monocytic cells." @default.
• W2045168631 created "2016-06-24" @default.
• W2045168631 creator A5058167698 @default.
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• W2045168631 date "1999-04-01" @default.
• W2045168631 modified "2023-10-14" @default.
• W2045168631 title "Human cytomegalovirus, MHC class I and inhibitory signalling receptors: more questions than answers" @default.
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• W2045168631 doi "https://doi.org/10.1111/j.1600-065x.1999.tb01292.x" @default.
• W2045168631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10399074" @default.
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