FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045171612> ?p ?o ?g. }

• W2045171612 endingPage "327" @default.
• W2045171612 startingPage "321" @default.
• W2045171612 abstract "Naturally occurring anti-band 3 antibodies (anti-band 3 NAbs) are directed against the 55-kDa chymotryptic fragment of the anion transport protein (band 3) of red blood cells (RBCs). They bind to senescent and oxidatively stressed RBCs and induce their selective clearance. These IgG NAbs exist at low concentrations, and have a weak affinity that prevents them from actively recruiting second binding sites. Cellular senescence or oxidative damage induces a cascade of biochemical events that results in the detachment of band 3 from the cytoskeleton and in clustering of band 3 protein by bound hemichromes and Syk kinase. Clustered band 3 proteins allow bivalent binding of anti-band 3 NAbs. Bivalently bound anti-band 3 NAbs have the unique capacity to stimulate C3b deposition by preferentially generating C3b2-IgG complexes, which act as potent C3 convertase precursors of the alternative complement pathway. Antibody binding not only to clustered, but also to oligomerized band 3 protein further increases if the human plasma also contains induced anti-lactoferrin antibodies. These bind to the polylactosaminyl oligosaccharide, a carbohydrate that exists in lactoferrin and in the 38-kDa fragment of band 3 protein. Anti-lactoferrin antibodies are found primarily in plasma of patients with autoimmune diseases and who have anti-neutrophil cytoplasmic antibodies (ANCA).Natürlicherweise vorkommende Anti-Bande-3-Antikörper (Anti-Bande-3-NAbs) sind gegen das chymotrypti-sche 55-kDa-Fragment des Anionenaustauschproteins der roten Blutkörperchen (RBCs) (Bande 3) gerichtet, binden an alte und oxidativ geschädigte RBCs und induzieren deren selektive Phagozytose. Diese NAbs sind IgG-Immunglobuline und haben eine schwache Affinität, welche sie daran hindert, aktiv Zweitbindungsstellen zu rekrutieren. Zelluläre Alterung oder oxidative Schädigungen induzieren eine Kaskade von biochemischen Vorgängen, die in der Ablösung der Bande-3-Proteine vom Zytoskelett resultieren und die Verklumpung von Bande 3 in der Membran durch die Bindung von Hemichromen und Syk-Kinase begünstigen. Verklumpte Bande-3-Proteine erlauben eine bivalente Bindung der Anti-Bande-3-NAbs. Bivalent gebundene Anti-Bande-3-NAbs haben die Fähigkeit, die C3b-Deposition zu stimulieren indem sie präferentiell C3b2-IgG bilden, die als potente Vorläufer von alternativen C3-Konvertasen wirken. Die Antikörper-Bindung nicht nur an verklumpte, sondern bereits an oligomerisierte Bande-3-Proteine steigt weiter an, wenn humanes Plasma auch induzierte Anti-Laktoferrin-Antikörper enthält, die an das Polylactosylaminyl-Kohlehydrat binden, das in Laktoferrin vorkommt aber auch im 38-kDa-Fragment des Bande-3-Proteins. Anti-Laktoferrin-Antikörper treten bevorzugt im Plasma von Patienten mit Autoimmunkrankheiten auf, insbesondere solchen, die sich durch anti-neutrophile zytoplasmatische Antikörper (ANCA) auszeichnen." @default.
• W2045171612 created "2016-06-24" @default.
• W2045171612 creator A5054243093 @default.
• W2045171612 date "2012-01-01" @default.
• W2045171612 modified "2023-09-30" @default.
• W2045171612 title "Naturally Occurring Anti-Band 3 Antibodies in Clearance of Senescent and Oxidatively Stressed Human Red Blood Cells" @default.
• W2045171612 cites W1489446940 @default.
• W2045171612 cites W1490691079 @default.
• W2045171612 cites W1497435349 @default.
• W2045171612 cites W1510676492 @default.
• W2045171612 cites W1512818335 @default.
• W2045171612 cites W1519544426 @default.
• W2045171612 cites W1527910795 @default.
• W2045171612 cites W1545202567 @default.
• W2045171612 cites W1551636999 @default.
• W2045171612 cites W1556109481 @default.
• W2045171612 cites W1559922603 @default.
• W2045171612 cites W1573469283 @default.
• W2045171612 cites W1583267779 @default.
• W2045171612 cites W1617605075 @default.
• W2045171612 cites W1637777503 @default.
• W2045171612 cites W171500453 @default.
• W2045171612 cites W1941960091 @default.
• W2045171612 cites W196272636 @default.
• W2045171612 cites W1967933991 @default.
• W2045171612 cites W1968323269 @default.
• W2045171612 cites W1970101659 @default.
• W2045171612 cites W1976579124 @default.
• W2045171612 cites W1984536917 @default.
• W2045171612 cites W1986645079 @default.
• W2045171612 cites W1990077900 @default.
• W2045171612 cites W1994868896 @default.
• W2045171612 cites W1996760725 @default.
• W2045171612 cites W2001191346 @default.
• W2045171612 cites W2004701417 @default.
• W2045171612 cites W2008159037 @default.
• W2045171612 cites W2013231179 @default.
• W2045171612 cites W2015500098 @default.
• W2045171612 cites W2016772022 @default.
• W2045171612 cites W2017827394 @default.
• W2045171612 cites W2026339206 @default.
• W2045171612 cites W2029612782 @default.
• W2045171612 cites W2031325281 @default.
• W2045171612 cites W2036042675 @default.
• W2045171612 cites W2038814048 @default.
• W2045171612 cites W2040332621 @default.
• W2045171612 cites W2040506150 @default.
• W2045171612 cites W2040534221 @default.
• W2045171612 cites W2043261147 @default.
• W2045171612 cites W2044434051 @default.
• W2045171612 cites W2047558995 @default.
• W2045171612 cites W2059663039 @default.
• W2045171612 cites W2061638766 @default.
• W2045171612 cites W2062141297 @default.
• W2045171612 cites W2066725658 @default.
• W2045171612 cites W2068653380 @default.
• W2045171612 cites W2073577737 @default.
• W2045171612 cites W2078743289 @default.
• W2045171612 cites W2084440999 @default.
• W2045171612 cites W2087763034 @default.
• W2045171612 cites W2089931492 @default.
• W2045171612 cites W2103305387 @default.
• W2045171612 cites W2113053099 @default.
• W2045171612 cites W2117583909 @default.
• W2045171612 cites W2119550023 @default.
• W2045171612 cites W2129429140 @default.
• W2045171612 cites W2141656646 @default.
• W2045171612 cites W2143381934 @default.
• W2045171612 cites W2148394321 @default.
• W2045171612 cites W2153836040 @default.
• W2045171612 cites W2154672378 @default.
• W2045171612 cites W2162732343 @default.
• W2045171612 cites W2163511143 @default.
• W2045171612 cites W2166465277 @default.
• W2045171612 cites W2413575217 @default.
• W2045171612 cites W70069252 @default.
• W2045171612 cites W83660317 @default.
• W2045171612 cites W8850113 @default.
• W2045171612 doi "https://doi.org/10.1159/000342171" @default.
• W2045171612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3678295" @default.
• W2045171612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23801923" @default.
• W2045171612 hasPublicationYear "2012" @default.
• W2045171612 type Work @default.
• W2045171612 sameAs 2045171612 @default.
• W2045171612 citedByCount "36" @default.
• W2045171612 countsByYear W20451716122012 @default.
• W2045171612 countsByYear W20451716122013 @default.
• W2045171612 countsByYear W20451716122015 @default.
• W2045171612 countsByYear W20451716122016 @default.
• W2045171612 countsByYear W20451716122017 @default.
• W2045171612 countsByYear W20451716122018 @default.
• W2045171612 countsByYear W20451716122019 @default.
• W2045171612 countsByYear W20451716122020 @default.
• W2045171612 countsByYear W20451716122021 @default.
• W2045171612 countsByYear W20451716122022 @default.
• W2045171612 countsByYear W20451716122023 @default.
• W2045171612 crossrefType "journal-article" @default.
• W2045171612 hasAuthorship W2045171612A5054243093 @default.

• next