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• W2045172044 abstract "Polysilicon nanowire biosensors have been fabricated using a top-down process and were used to determine the binding constant of two inflammatory biomarkers. A very low cost nanofabrication process was developed, based on simple and mature photolithography, thin film technology, and plasma etching, enabling an easy route to mass manufacture. Antibody-functionalized nanowire sensors were used to detect the proteins interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) over a wide range of concentrations, demonstrating excellent sensitivity and selectivity, exemplified by a detection sensitivity of 10 fM in the presence of a 100 000-fold excess of a nontarget protein. Nanowire titration curves gave antibody–antigen dissociation constants in good agreement with low-salt enzyme-linked immunosorbent assays (ELISAs). This fabrication process produces high-quality nanowires that are suitable for low-cost mass production, providing a realistic route to the realization of disposable nanoelectronic point-of-care (PoC) devices." @default.
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• W2045172044 date "2012-03-26" @default.
• W2045172044 modified "2023-09-29" @default.
• W2045172044 title "Thin Film Polycrystalline Silicon Nanowire Biosensors" @default.
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• W2045172044 doi "https://doi.org/10.1021/nl2042276" @default.
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