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- W2045172389 abstract "We have previously demonstrated that brain lesions caused by stroke led to the lateralization of T‐cell dependent inflammation. The purpose of this study was to assess the impact of localization of the brain lesion on lateralization of immune responsiveness. The delayed‐type hypersensitivity (DTH) reaction was used as an in vivo measure of antigen specific T‐lymphocyte reactivity. All stroke patients were examined with computed scan tomography (CT) of the brain to ascertain the localization and extent of the brain lesion. Patients with right‐sided brain lesions displayed significantly larger ( P = 0.008) DTH responses on the paretic side compared to the contralateral side. Detailed analysis of the localization of the brain lesion revealed that infarcts encompassing frontal lobe–putamen led to significantly larger ( P = 0.007) DTH responses on the paretic side compared to the contralateral side. Localization of the brain lesion affects the lateralization of DTH, supporting an asymmetrical modulation of the immune response. In addition, our study points to the frontal cortex–putamen as a putative brain centre regulating the magnitude of immune responses." @default.
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- W2045172389 date "1998-01-01" @default.
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- W2045172389 title "Localization of the Brain Lesion Affects the Lateralization of T‐Lymphocyte Dependent Cutaneous Inflammation. Evidence for an Immunoregulatory Role of the Right Frontal Cortex–Putamen Region" @default.
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- W2045172389 doi "https://doi.org/10.1046/j.1365-3083.1998.00243.x" @default.
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