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• W2045177435 abstract "PurposeWe sought to determine whether tests for fetal aneuploidy based on next-generation sequencing of cell-free DNA in maternal circulation have had an impact on routine serum-based screening in the general pregnant population.MethodsWe compared results from laboratory surveys in 2011 and 2014 that reported types of prenatal serum screening tests and numbers of tests performed. Testing records from two prenatal serum screening laboratories examined temporal trends in the proportion of screened women 35 years of age and older from 2008 (or 2009) to 2014.ResultsThe 82 laboratory survey results available for comparison showed that 1.7 million women were screened in 2014, a 5% increase over 2011. In the two screening laboratories, the proportion of screened women age 35 and older increased for several years but then experienced reductions of 8 and 18% by mid-2014 when compared with the highest rates observed.ConclusionAs of 2014, maternal plasma DNA testing appears to have had only a minor impact on serum screening rates in the United States. Ongoing surveillance has the potential to determine if, and when, DNA testing begins to replace serum testing as a primary screen for Down syndrome in the United States.Genet Med17 11, 897–900." @default.
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• W2045177435 date "2015-11-01" @default.
• W2045177435 modified "2023-09-23" @default.
• W2045177435 title "Is maternal plasma DNA testing impacting serum-based screening for aneuploidy in the United States?" @default.
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• W2045177435 doi "https://doi.org/10.1038/gim.2015.39" @default.
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