Matches in SemOpenAlex for { <https://semopenalex.org/work/W204518069> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W204518069 endingPage "30" @default.
- W204518069 startingPage "23" @default.
- W204518069 abstract "Impairment of macrophage phagocytosis is a major cause of chronic inflammation. Bisphosphonates (BPs) are widely used as anti-osteoclastic agents. The effects of BPs on monocyte-macrophage lineage cells are being increasingly reported; however, the detailed effects of BPs on macrophage phagocytic activity are still unclear. We examined the effects of four BPs: clodronate as a non-nitrogen containing BP (non-N-BP), and pamidronate, alendronate, and zoledronate as nitrogen-containing BP(N-BP), on macrophage phagocytic activity. The uptake of high fluorescence-labeled polystyrene beads by the human monocytic cell line THP-1 was investigated by flow cytometry. All three N-BPs suppressed the phagocytosis of macrophages more potently than the non-N-BP, clodronate. Pamidronate and zoledronate were more potent than alendronate. BP induced the apoptosis of THP-1. Pamidronate and zoledronate induced apoptosis more effectively than clodronate. The method described to observe phagocytosis was simple and quantitative, and might be useful in screening for the effects of drugs, such as N-BP and non-N-BP, on phagocytic activity." @default.
- W204518069 created "2016-06-24" @default.
- W204518069 creator A5004769553 @default.
- W204518069 creator A5004776824 @default.
- W204518069 creator A5019821403 @default.
- W204518069 creator A5084762368 @default.
- W204518069 creator A5008721791 @default.
- W204518069 date "2014-01-01" @default.
- W204518069 modified "2023-09-23" @default.
- W204518069 title "[Effects of four bisphosphonates on macrophage phagocytosis: quantitative measurement by flow cytometry using high-fluorescence particles and human monocytic cell line THP-1]." @default.
- W204518069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24724423" @default.
- W204518069 hasPublicationYear "2014" @default.
- W204518069 type Work @default.
- W204518069 sameAs 204518069 @default.
- W204518069 citedByCount "1" @default.
- W204518069 countsByYear W2045180692015 @default.
- W204518069 crossrefType "journal-article" @default.
- W204518069 hasAuthorship W204518069A5004769553 @default.
- W204518069 hasAuthorship W204518069A5004776824 @default.
- W204518069 hasAuthorship W204518069A5008721791 @default.
- W204518069 hasAuthorship W204518069A5019821403 @default.
- W204518069 hasAuthorship W204518069A5084762368 @default.
- W204518069 hasConcept C153911025 @default.
- W204518069 hasConcept C160448771 @default.
- W204518069 hasConcept C185592680 @default.
- W204518069 hasConcept C190283241 @default.
- W204518069 hasConcept C202751555 @default.
- W204518069 hasConcept C203014093 @default.
- W204518069 hasConcept C204258353 @default.
- W204518069 hasConcept C2776914184 @default.
- W204518069 hasConcept C2779244956 @default.
- W204518069 hasConcept C2781184567 @default.
- W204518069 hasConcept C502942594 @default.
- W204518069 hasConcept C54355233 @default.
- W204518069 hasConcept C553184892 @default.
- W204518069 hasConcept C55493867 @default.
- W204518069 hasConcept C81885089 @default.
- W204518069 hasConcept C86803240 @default.
- W204518069 hasConcept C98274493 @default.
- W204518069 hasConceptScore W204518069C153911025 @default.
- W204518069 hasConceptScore W204518069C160448771 @default.
- W204518069 hasConceptScore W204518069C185592680 @default.
- W204518069 hasConceptScore W204518069C190283241 @default.
- W204518069 hasConceptScore W204518069C202751555 @default.
- W204518069 hasConceptScore W204518069C203014093 @default.
- W204518069 hasConceptScore W204518069C204258353 @default.
- W204518069 hasConceptScore W204518069C2776914184 @default.
- W204518069 hasConceptScore W204518069C2779244956 @default.
- W204518069 hasConceptScore W204518069C2781184567 @default.
- W204518069 hasConceptScore W204518069C502942594 @default.
- W204518069 hasConceptScore W204518069C54355233 @default.
- W204518069 hasConceptScore W204518069C553184892 @default.
- W204518069 hasConceptScore W204518069C55493867 @default.
- W204518069 hasConceptScore W204518069C81885089 @default.
- W204518069 hasConceptScore W204518069C86803240 @default.
- W204518069 hasConceptScore W204518069C98274493 @default.
- W204518069 hasIssue "1" @default.
- W204518069 hasLocation W2045180691 @default.
- W204518069 hasOpenAccess W204518069 @default.
- W204518069 hasPrimaryLocation W2045180691 @default.
- W204518069 hasRelatedWork W1580038353 @default.
- W204518069 hasRelatedWork W1992147208 @default.
- W204518069 hasRelatedWork W2028288720 @default.
- W204518069 hasRelatedWork W204518069 @default.
- W204518069 hasRelatedWork W2085939460 @default.
- W204518069 hasRelatedWork W2086326291 @default.
- W204518069 hasRelatedWork W2355195107 @default.
- W204518069 hasRelatedWork W2368233448 @default.
- W204518069 hasRelatedWork W2410121633 @default.
- W204518069 hasRelatedWork W2581881105 @default.
- W204518069 hasVolume "62" @default.
- W204518069 isParatext "false" @default.
- W204518069 isRetracted "false" @default.
- W204518069 magId "204518069" @default.
- W204518069 workType "article" @default.