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• W2045181508 startingPage "745" @default.
• W2045181508 abstract "Increases in the levels and/or activity of nonreceptor tyrosine kinases c-Src and c-Yes are often associated with colorectal carcinogenesis. The physiological consequences of increased c-Yes activity during the early and late stages of tumorigenesis, in addition to the degree of redundancy between c-Yes and c-Src in colorectal cancer cells, remain elusive. To study the consequences of increases in c-Yes levels and activity in later stages of colorectal carcinogenesis, we developed human colorectal cancer cell lines in which c-Yes levels and activity can be inducibly increased by a tightly controlled expression of wild-type c-Yes or by constitutively active mutants of c-Yes, c-YesY537F, and c-Yes Delta t6aa. c-Yes induction resulted in increased cell motility but did not promote proliferation either in vitro or in vivo. These results suggest that in later stages of colorectal carcinogenesis, elevations in c-Yes levels/activity may promote cancer spread and metastasis rather than tumor growth." @default.
• W2045181508 created "2016-06-24" @default.
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• W2045181508 date "2007-09-01" @default.
• W2045181508 modified "2023-10-13" @default.
• W2045181508 title "Increases in c-Yes Expression Level and Activity Promote Motility But Not Proliferation of Human Colorectal Carcinoma Cells" @default.
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• W2045181508 doi "https://doi.org/10.1593/neo.07442" @default.
• W2045181508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1993859" @default.
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