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- W2045181745 abstract "To the Editor:— This communication is prompted by the Current Comment in the July 17 issue ofThe Journal, page 812. It concerns the remarkable findings by Chamelin and Funk that injections of whole liver reduced the toxicity of sulfanilamide and diethylstilbestrol in rats. Certain experiments that I have done lead me to believe that the action of whole liver extract in ameliorating the toxic effects against both of these substances is through its high content of ascorbic acid. It has long been known that liver, next to the adrenal glands, contains more ascorbic acid than all other animal tissues (Aron, H., and others:Jahrb. f. Kinderh.1:123, 1921). The effect of ascorbic acid in reducing the toxic effects of neoarsphenamine is also well known (Sulzberger, M. B., and Oser, B. L.:Proc. Soc. Exper. Biol. & Med.32:716, 1934). Recently I was able to reduce the sensitivity" @default.
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- W2045181745 date "1943-09-11" @default.
- W2045181745 modified "2023-09-26" @default.
- W2045181745 title "USE OF LIVER TO OVERCOME TOXICITY OF SULFONAMIDES" @default.
- W2045181745 doi "https://doi.org/10.1001/jama.1943.02840370045019" @default.
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