Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045182023> ?p ?o ?g. }
- W2045182023 endingPage "172" @default.
- W2045182023 startingPage "162" @default.
- W2045182023 abstract "Kindling, an experimental model of epileptogenesis, and activation-induced synaptic reorganization are modulated by nerve growth factor (NGF), but whether NGF acts via its high-affinity receptor TrkA and/or the common neurotrophin receptor p75NTR is unknown. We previously demonstrated, and confirmed in this study, that inhibition of NGF binding to both TrkA and p75NTR inhibited kindling and decreased kindling-induced mossy fiber sprouting. We now report specific inhibition of TrkA·NGF binding, but not p75NTR·NGF binding, retarded perforant path kindling progression. However, mossy fiber sprouting was inhibited by either selective TrkA·NGF or p75NTR·NGF antagonists. Our results suggest that TrkA, but not p75NTR, plays a role in kindling, while both receptors modulate kindling-induced mossy fiber sprouting. This implicates different mechanisms of neurotrophin action on kindling (mediated by TrkA) and neuronal sprouting (mediated by both TrkA and p75NTR) and suggests that sprouting involves kindling-independent neurotrophin action via p75NTR." @default.
- W2045182023 created "2016-06-24" @default.
- W2045182023 creator A5011808166 @default.
- W2045182023 creator A5022794010 @default.
- W2045182023 creator A5043600072 @default.
- W2045182023 creator A5061357662 @default.
- W2045182023 creator A5075943140 @default.
- W2045182023 creator A5077323080 @default.
- W2045182023 date "2005-06-01" @default.
- W2045182023 modified "2023-10-16" @default.
- W2045182023 title "Differential actions of nerve growth factor receptors TrkA and p75NTR in a rat model of epileptogenesis" @default.
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