FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045184088> ?p ?o ?g. }

• W2045184088 endingPage "346" @default.
• W2045184088 startingPage "339" @default.
• W2045184088 abstract "Cholecystokinin (CCK) binding sites were solubilized from pig cerebral cortical membranes with digitonin (2%, w/v) in the presence of Na+ (120 mM) and Mg2+ (5 mM). Scatchard plot transformation of equilibrium binding data obtained with 125I-CCK-8S gave an apparent dissociation constant (Kd) of 0.6 nM, comparable to that obtained in membranes in the presence of these cations. Hill coefficients close to unity suggested the presence of a single population of receptor sites. Competitive inhibition studies with pentagastrin, gastrin(1-17)S and the CCKA receptor antagonist L-364,718 indicated that the solubilized receptor sites were of the B-type (CCKB), with the same pharmacological profile as that observed in membranes. Optimal specific binding of 125I-CCK-8S to membrane-bound and solubilized receptors was obtained in the presence of divalent cations. Both the membrane-bound and the solubilized receptor activity were attenuated by guanylyl-imidodiphosphate (Gpp(NH)p) indicating that the brain CCKB receptors are coupled to G proteins." @default.
• W2045184088 created "2016-06-24" @default.
• W2045184088 creator A5027498764 @default.
• W2045184088 creator A5054554864 @default.
• W2045184088 creator A5056738653 @default.
• W2045184088 creator A5078255099 @default.
• W2045184088 creator A5086679592 @default.
• W2045184088 date "1989-10-01" @default.
• W2045184088 modified "2023-09-25" @default.
• W2045184088 title "Solubilization and characterization of the cholecystokininB binding site from pig cerebral cortex" @default.
• W2045184088 cites W159198934 @default.
• W2045184088 cites W164162904 @default.
• W2045184088 cites W1682371140 @default.
• W2045184088 cites W1933591933 @default.
• W2045184088 cites W1984330748 @default.
• W2045184088 cites W1985106869 @default.
• W2045184088 cites W1990138172 @default.
• W2045184088 cites W1991714764 @default.
• W2045184088 cites W1993467791 @default.
• W2045184088 cites W1997891738 @default.
• W2045184088 cites W1998184571 @default.
• W2045184088 cites W2010119268 @default.
• W2045184088 cites W2013728409 @default.
• W2045184088 cites W2027107497 @default.
• W2045184088 cites W2031666953 @default.
• W2045184088 cites W2043813981 @default.
• W2045184088 cites W2044465881 @default.
• W2045184088 cites W2044717475 @default.
• W2045184088 cites W2058423921 @default.
• W2045184088 cites W2061070426 @default.
• W2045184088 cites W2066462196 @default.
• W2045184088 cites W2068074913 @default.
• W2045184088 cites W2069556768 @default.
• W2045184088 cites W2074631079 @default.
• W2045184088 cites W2079804757 @default.
• W2045184088 cites W2080413833 @default.
• W2045184088 cites W2091855218 @default.
• W2045184088 cites W2140097465 @default.
• W2045184088 cites W2222512631 @default.
• W2045184088 cites W4293247451 @default.
• W2045184088 doi "https://doi.org/10.1016/0922-4106(89)90014-x" @default.
• W2045184088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2583245" @default.
• W2045184088 hasPublicationYear "1989" @default.
• W2045184088 type Work @default.
• W2045184088 sameAs 2045184088 @default.
• W2045184088 citedByCount "12" @default.
• W2045184088 crossrefType "journal-article" @default.
• W2045184088 hasAuthorship W2045184088A5027498764 @default.
• W2045184088 hasAuthorship W2045184088A5054554864 @default.
• W2045184088 hasAuthorship W2045184088A5056738653 @default.
• W2045184088 hasAuthorship W2045184088A5078255099 @default.
• W2045184088 hasAuthorship W2045184088A5086679592 @default.
• W2045184088 hasConcept C107824862 @default.
• W2045184088 hasConcept C12554922 @default.
• W2045184088 hasConcept C144024400 @default.
• W2045184088 hasConcept C149923435 @default.
• W2045184088 hasConcept C170493617 @default.
• W2045184088 hasConcept C178790620 @default.
• W2045184088 hasConcept C185592680 @default.
• W2045184088 hasConcept C2777593968 @default.
• W2045184088 hasConcept C2778920010 @default.
• W2045184088 hasConcept C2908647359 @default.
• W2045184088 hasConcept C32110497 @default.
• W2045184088 hasConcept C41625074 @default.
• W2045184088 hasConcept C55493867 @default.
• W2045184088 hasConcept C71240020 @default.
• W2045184088 hasConcept C74884574 @default.
• W2045184088 hasConcept C74998103 @default.
• W2045184088 hasConcept C86803240 @default.
• W2045184088 hasConceptScore W2045184088C107824862 @default.
• W2045184088 hasConceptScore W2045184088C12554922 @default.
• W2045184088 hasConceptScore W2045184088C144024400 @default.
• W2045184088 hasConceptScore W2045184088C149923435 @default.
• W2045184088 hasConceptScore W2045184088C170493617 @default.
• W2045184088 hasConceptScore W2045184088C178790620 @default.
• W2045184088 hasConceptScore W2045184088C185592680 @default.
• W2045184088 hasConceptScore W2045184088C2777593968 @default.
• W2045184088 hasConceptScore W2045184088C2778920010 @default.
• W2045184088 hasConceptScore W2045184088C2908647359 @default.
• W2045184088 hasConceptScore W2045184088C32110497 @default.
• W2045184088 hasConceptScore W2045184088C41625074 @default.
• W2045184088 hasConceptScore W2045184088C55493867 @default.
• W2045184088 hasConceptScore W2045184088C71240020 @default.
• W2045184088 hasConceptScore W2045184088C74884574 @default.
• W2045184088 hasConceptScore W2045184088C74998103 @default.
• W2045184088 hasConceptScore W2045184088C86803240 @default.
• W2045184088 hasIssue "4-5" @default.
• W2045184088 hasLocation W20451840881 @default.
• W2045184088 hasLocation W20451840882 @default.
• W2045184088 hasOpenAccess W2045184088 @default.
• W2045184088 hasPrimaryLocation W20451840881 @default.
• W2045184088 hasRelatedWork W1974585084 @default.
• W2045184088 hasRelatedWork W1999248599 @default.
• W2045184088 hasRelatedWork W2015125915 @default.
• W2045184088 hasRelatedWork W2028307374 @default.
• W2045184088 hasRelatedWork W2045184088 @default.
• W2045184088 hasRelatedWork W2066462196 @default.
• W2045184088 hasRelatedWork W2066944012 @default.

• next