Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045186739> ?p ?o ?g. }
- W2045186739 endingPage "675" @default.
- W2045186739 startingPage "655" @default.
- W2045186739 abstract "Entamoeba, Giardia, and trichomonads are the prominent members of a group known as 'mucosal parasites'. While Entamoeba and Giardia trophozoites colonise the small intestine, trichomonads inhabit the genitourinary tracts of humans and animals. These protozoa lack mitochondria, well-developed Golgi complexes, and other organelles typical of higher eukaryotes. Nonetheless, they have developed unique metabolic pathways that allow them to survive and multiply in the small intestine and reproductive tracts by scavenging nutrients from the host. Various investigators have shown that these protozoa are unable to synthesise the majority of their own lipids and cholesterol de novo; rather, they depend mostly on supplies from outside sources. Therefore, questions of how they transport and utilise exogenous lipids for metabolic purposes are extremely important. There is evidence suggesting that these parasites can take up the lipids and cholesterol they need from lipoprotein particles present in the host and/or in the growth medium. Studies also support the idea that individual lipid and fatty acid molecules can be transported without the help of lipoproteins. Exogenous phospholipids have been shown to undergo fatty acid remodelling (by deacylation/reacylation reactions), which allows these protozoa to alter lipids, bypassing the synthesis of entirely new phospholipid molecules. In addition, many of these amitochondriates are, however, capable of elongating/desaturating long-chain fatty acids, and assembling novel glycophospholipid molecules. In this review, progress in various aspects of lipid research on these organisms is discussed. Attempts are also made to identify steps of lipid metabolic pathways that can be used to develop chemotherapeutic agents against these and other mucosal parasites." @default.
- W2045186739 created "2016-06-24" @default.
- W2045186739 creator A5004725419 @default.
- W2045186739 creator A5038575466 @default.
- W2045186739 creator A5039369488 @default.
- W2045186739 creator A5041020333 @default.
- W2045186739 creator A5057559350 @default.
- W2045186739 creator A5074865308 @default.
- W2045186739 date "2002-06-01" @default.
- W2045186739 modified "2023-10-12" @default.
- W2045186739 title "Lipid metabolism in mucous-dwelling amitochondriate protozoa" @default.
- W2045186739 cites W13308625 @default.
- W2045186739 cites W1483932958 @default.
- W2045186739 cites W1506172251 @default.
- W2045186739 cites W1536896823 @default.
- W2045186739 cites W1573258040 @default.
- W2045186739 cites W1590482447 @default.
- W2045186739 cites W1607374610 @default.
- W2045186739 cites W1634039594 @default.
- W2045186739 cites W1638433242 @default.
- W2045186739 cites W1825054543 @default.
- W2045186739 cites W1837167077 @default.
- W2045186739 cites W1881778502 @default.
- W2045186739 cites W1897997059 @default.
- W2045186739 cites W1915912984 @default.
- W2045186739 cites W1916035994 @default.
- W2045186739 cites W1919328013 @default.
- W2045186739 cites W1944304173 @default.
- W2045186739 cites W1952053657 @default.
- W2045186739 cites W1964393743 @default.
- W2045186739 cites W1966996832 @default.
- W2045186739 cites W1967139016 @default.
- W2045186739 cites W1967185063 @default.
- W2045186739 cites W1967269935 @default.
- W2045186739 cites W1975579893 @default.
- W2045186739 cites W1979891544 @default.
- W2045186739 cites W1980424273 @default.
- W2045186739 cites W1980906332 @default.
- W2045186739 cites W1981979522 @default.
- W2045186739 cites W1986124196 @default.
- W2045186739 cites W1987022258 @default.
- W2045186739 cites W198728231 @default.
- W2045186739 cites W1988408072 @default.
- W2045186739 cites W1988617854 @default.
- W2045186739 cites W1990081839 @default.
- W2045186739 cites W1991321700 @default.
- W2045186739 cites W1991343143 @default.
- W2045186739 cites W1999389101 @default.
- W2045186739 cites W1999409280 @default.
- W2045186739 cites W1999460063 @default.
- W2045186739 cites W2002842011 @default.
- W2045186739 cites W2003227802 @default.
- W2045186739 cites W2005973826 @default.
- W2045186739 cites W2006939584 @default.
- W2045186739 cites W2013021354 @default.
- W2045186739 cites W2013827094 @default.
- W2045186739 cites W2016185570 @default.
- W2045186739 cites W2016320987 @default.
- W2045186739 cites W2016675624 @default.
- W2045186739 cites W2022399895 @default.
- W2045186739 cites W2022658293 @default.
- W2045186739 cites W2023021733 @default.
- W2045186739 cites W2023490858 @default.
- W2045186739 cites W2024864454 @default.
- W2045186739 cites W2026555484 @default.
- W2045186739 cites W2027833479 @default.
- W2045186739 cites W2028270709 @default.
- W2045186739 cites W2028448607 @default.
- W2045186739 cites W2029063203 @default.
- W2045186739 cites W2029617555 @default.
- W2045186739 cites W2030823707 @default.
- W2045186739 cites W2032072281 @default.
- W2045186739 cites W2032388023 @default.
- W2045186739 cites W2032487741 @default.
- W2045186739 cites W2035822577 @default.
- W2045186739 cites W2037085464 @default.
- W2045186739 cites W2041239295 @default.
- W2045186739 cites W2043207375 @default.
- W2045186739 cites W2043313847 @default.
- W2045186739 cites W2044493561 @default.
- W2045186739 cites W2045988210 @default.
- W2045186739 cites W2046365038 @default.
- W2045186739 cites W2046604866 @default.
- W2045186739 cites W2046923170 @default.
- W2045186739 cites W2049806808 @default.
- W2045186739 cites W2052343832 @default.
- W2045186739 cites W2052360755 @default.
- W2045186739 cites W2052667046 @default.
- W2045186739 cites W2053533795 @default.
- W2045186739 cites W2057100489 @default.
- W2045186739 cites W2062419164 @default.
- W2045186739 cites W2068725935 @default.
- W2045186739 cites W2068918663 @default.
- W2045186739 cites W2069283492 @default.
- W2045186739 cites W2071232514 @default.
- W2045186739 cites W2074907070 @default.
- W2045186739 cites W2076767566 @default.
- W2045186739 cites W2081426482 @default.