FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045194946> ?p ?o ?g. }

• W2045194946 endingPage "110" @default.
• W2045194946 startingPage "102" @default.
• W2045194946 abstract "Folate molecules self-assemble in the form of stacks to form liquid-crystalline solutions. Nanocarriers from self-assembled folates are composed of highly ordered structures, which offer high encapsulation of drug (95–98%), controlled drug release rates, active cellular uptake and biocompatibility. Recently, we have shown that the release rates of methotrexate can be controlled by varying the size of nanoparticles, cross-linking cation and cross-linking concentration. The present study reports the in vitro cytotoxic behavior of methotrexate loaded liquid-crystalline folate nanoparticles on cultured HeLa cells. Changing drug release rates can influence cytotoxicity of cancer cells. Therefore, to study the correlation of release rate and cytotoxic behavior, the effect of release controlling parameters on HeLa cells was studied through MTT assay. It is reported that by controlling the methotrexate release, the survival rates of HeLa cells can be controlled. Released methotrexate kills HeLa cells as effectively as free methotrexate solution. The co-culture based in vitro cellular uptake study through fluorescence microscopy on folate receptor positive and negative cancer cells shows that the present nanocarrier has the potential to distinguish cancer cells from normal cells. Overall, the present study reports the in vitro performance of self-assembled liquid-crystalline folate nanoparticles, which will be a platform for further in vivo studies and clinical trials." @default.
• W2045194946 created "2016-06-24" @default.
• W2045194946 creator A5011164297 @default.
• W2045194946 creator A5056435334 @default.
• W2045194946 creator A5079700335 @default.
• W2045194946 creator A5088997508 @default.
• W2045194946 date "2015-02-01" @default.
• W2045194946 modified "2023-09-26" @default.
• W2045194946 title "In vitro control release, cytotoxicity assessment and cellular uptake of methotrexate loaded liquid-crystalline folate nanocarrier" @default.
• W2045194946 cites W1974651535 @default.
• W2045194946 cites W1975556125 @default.
• W2045194946 cites W1984811407 @default.
• W2045194946 cites W1991337384 @default.
• W2045194946 cites W1992437490 @default.
• W2045194946 cites W1995672180 @default.
• W2045194946 cites W1998020789 @default.
• W2045194946 cites W2005876018 @default.
• W2045194946 cites W2013983587 @default.
• W2045194946 cites W2016057307 @default.
• W2045194946 cites W2016340659 @default.
• W2045194946 cites W2019246838 @default.
• W2045194946 cites W2029565337 @default.
• W2045194946 cites W2033281188 @default.
• W2045194946 cites W2036850145 @default.
• W2045194946 cites W2043235071 @default.
• W2045194946 cites W2063606043 @default.
• W2045194946 cites W2070124760 @default.
• W2045194946 cites W2072754176 @default.
• W2045194946 cites W2079866087 @default.
• W2045194946 cites W2084357980 @default.
• W2045194946 cites W2088377627 @default.
• W2045194946 cites W2088779155 @default.
• W2045194946 cites W2091328845 @default.
• W2045194946 cites W2104993716 @default.
• W2045194946 cites W2110150885 @default.
• W2045194946 cites W2112148510 @default.
• W2045194946 cites W2114931505 @default.
• W2045194946 cites W2118991777 @default.
• W2045194946 cites W2119553322 @default.
• W2045194946 cites W2129685558 @default.
• W2045194946 cites W2133538780 @default.
• W2045194946 cites W2146802420 @default.
• W2045194946 cites W2147171841 @default.
• W2045194946 cites W2314844014 @default.
• W2045194946 cites W2318404674 @default.
• W2045194946 cites W2590390086 @default.
• W2045194946 doi "https://doi.org/10.1016/j.biopha.2014.11.012" @default.
• W2045194946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25661345" @default.
• W2045194946 hasPublicationYear "2015" @default.
• W2045194946 type Work @default.
• W2045194946 sameAs 2045194946 @default.
• W2045194946 citedByCount "10" @default.
• W2045194946 countsByYear W20451949462015 @default.
• W2045194946 countsByYear W20451949462016 @default.
• W2045194946 countsByYear W20451949462017 @default.
• W2045194946 countsByYear W20451949462018 @default.
• W2045194946 countsByYear W20451949462019 @default.
• W2045194946 countsByYear W20451949462020 @default.
• W2045194946 countsByYear W20451949462021 @default.
• W2045194946 crossrefType "journal-article" @default.
• W2045194946 hasAuthorship W2045194946A5011164297 @default.
• W2045194946 hasAuthorship W2045194946A5056435334 @default.
• W2045194946 hasAuthorship W2045194946A5079700335 @default.
• W2045194946 hasAuthorship W2045194946A5088997508 @default.
• W2045194946 hasConcept C109316439 @default.
• W2045194946 hasConcept C121608353 @default.
• W2045194946 hasConcept C12554922 @default.
• W2045194946 hasConcept C150903083 @default.
• W2045194946 hasConcept C154317977 @default.
• W2045194946 hasConcept C163588942 @default.
• W2045194946 hasConcept C171250308 @default.
• W2045194946 hasConcept C178790620 @default.
• W2045194946 hasConcept C18150654 @default.
• W2045194946 hasConcept C185592680 @default.
• W2045194946 hasConcept C192562407 @default.
• W2045194946 hasConcept C202751555 @default.
• W2045194946 hasConcept C203014093 @default.
• W2045194946 hasConcept C207001950 @default.
• W2045194946 hasConcept C2777230088 @default.
• W2045194946 hasConcept C2777366897 @default.
• W2045194946 hasConcept C2779820397 @default.
• W2045194946 hasConcept C2780306303 @default.
• W2045194946 hasConcept C2780783641 @default.
• W2045194946 hasConcept C2781059491 @default.
• W2045194946 hasConcept C54355233 @default.
• W2045194946 hasConcept C55493867 @default.
• W2045194946 hasConcept C86803240 @default.
• W2045194946 hasConcept C96232424 @default.
• W2045194946 hasConceptScore W2045194946C109316439 @default.
• W2045194946 hasConceptScore W2045194946C121608353 @default.
• W2045194946 hasConceptScore W2045194946C12554922 @default.
• W2045194946 hasConceptScore W2045194946C150903083 @default.
• W2045194946 hasConceptScore W2045194946C154317977 @default.
• W2045194946 hasConceptScore W2045194946C163588942 @default.
• W2045194946 hasConceptScore W2045194946C171250308 @default.
• W2045194946 hasConceptScore W2045194946C178790620 @default.
• W2045194946 hasConceptScore W2045194946C18150654 @default.
• W2045194946 hasConceptScore W2045194946C185592680 @default.

• next