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- W2045196165 abstract "Molecular targeted therapies in metastatic melanoma Rima Chakraborty,1 Carilyn N Wieland,2 Nneka I Comfere2 1University of Missouri-Kansas City Medical School, Kansas City, MO, 2Departments of Dermatology and Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA Abstract: The advent of personalized medicine has ushered in a new era for cancer therapy with a significant impact on the management of advanced melanoma. Molecular targeted therapies have shown promise in the management of various malignancies, including melanoma, with lower toxicity profiles and better overall survival as compared with conventional therapy. The discovery of BRAF mutations in melanoma led to the development of BRAF inhibitors for the treatment of advanced melanoma. However, growing concerns over drug resistance to molecular targeted therapies including BRAF inhibitors, have spurred efforts to elucidate additional molecular targets for the treatment of advanced melanoma. In this review, we discuss the known molecular aberrations in melanoma, current and novel targeted approaches in its treatment, and drug resistance patterns. Keywords: BRAF inhibitors, metastatic melanoma, personalized medicine" @default.
- W2045196165 created "2016-06-24" @default.
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- W2045196165 date "2013-06-01" @default.
- W2045196165 modified "2023-09-27" @default.
- W2045196165 title "Molecular targeted therapies in metastatic melanoma" @default.
- W2045196165 cites W1490151519 @default.
- W2045196165 cites W1499291662 @default.
- W2045196165 cites W1607548879 @default.
- W2045196165 cites W1773110831 @default.
- W2045196165 cites W1819426498 @default.
- W2045196165 cites W1879616740 @default.
- W2045196165 cites W1917632054 @default.
- W2045196165 cites W1950572133 @default.
- W2045196165 cites W1968664688 @default.
- W2045196165 cites W1971050728 @default.
- W2045196165 cites W1974004551 @default.
- W2045196165 cites W1978580213 @default.
- W2045196165 cites W1982289269 @default.
- W2045196165 cites W1984606443 @default.
- W2045196165 cites W1986076152 @default.
- W2045196165 cites W1987633199 @default.
- W2045196165 cites W1994376203 @default.
- W2045196165 cites W1997919830 @default.
- W2045196165 cites W1998938134 @default.
- W2045196165 cites W1999691765 @default.
- W2045196165 cites W2007964976 @default.
- W2045196165 cites W2011257826 @default.
- W2045196165 cites W2011852843 @default.
- W2045196165 cites W2012478862 @default.
- W2045196165 cites W2014205794 @default.
- W2045196165 cites W2014881369 @default.
- W2045196165 cites W2015015957 @default.
- W2045196165 cites W2017187984 @default.
- W2045196165 cites W2018155127 @default.
- W2045196165 cites W2030082201 @default.
- W2045196165 cites W2032211985 @default.
- W2045196165 cites W2034048944 @default.
- W2045196165 cites W2036057459 @default.
- W2045196165 cites W2055366803 @default.
- W2045196165 cites W2056199226 @default.
- W2045196165 cites W2056578809 @default.
- W2045196165 cites W2070871778 @default.
- W2045196165 cites W2071113489 @default.
- W2045196165 cites W2073363047 @default.
- W2045196165 cites W2080621968 @default.
- W2045196165 cites W2080719056 @default.
- W2045196165 cites W2080786702 @default.
- W2045196165 cites W2087219825 @default.
- W2045196165 cites W2096223992 @default.
- W2045196165 cites W2097096041 @default.
- W2045196165 cites W2097995306 @default.
- W2045196165 cites W2099200814 @default.
- W2045196165 cites W2101653483 @default.
- W2045196165 cites W2102352867 @default.
- W2045196165 cites W2103845135 @default.
- W2045196165 cites W2106543129 @default.
- W2045196165 cites W2109545379 @default.
- W2045196165 cites W2111863560 @default.
- W2045196165 cites W2115693635 @default.
- W2045196165 cites W2123363005 @default.
- W2045196165 cites W2128542677 @default.
- W2045196165 cites W2131906164 @default.
- W2045196165 cites W2133441070 @default.
- W2045196165 cites W2135925159 @default.
- W2045196165 cites W2136474966 @default.
- W2045196165 cites W2139249310 @default.
- W2045196165 cites W2139684524 @default.
- W2045196165 cites W2141171750 @default.
- W2045196165 cites W2141529421 @default.
- W2045196165 cites W2141674733 @default.
- W2045196165 cites W2147474070 @default.
- W2045196165 cites W2155305032 @default.
- W2045196165 cites W2155461614 @default.
- W2045196165 cites W2156078931 @default.
- W2045196165 cites W2156228893 @default.
- W2045196165 cites W2156266404 @default.
- W2045196165 cites W2157210705 @default.
- W2045196165 cites W2160378889 @default.
- W2045196165 cites W2163188200 @default.
- W2045196165 cites W2166262263 @default.
- W2045196165 cites W2168143310 @default.
- W2045196165 cites W2171367970 @default.
- W2045196165 cites W2172049434 @default.
- W2045196165 cites W2269193607 @default.
- W2045196165 cites W2521042874 @default.
- W2045196165 cites W2565709407 @default.
- W2045196165 doi "https://doi.org/10.2147/pgpm.s44800" @default.
- W2045196165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3702032" @default.
- W2045196165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23843700" @default.
- W2045196165 hasPublicationYear "2013" @default.
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