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• W2045196759 abstract "The effects of acute and chronic treatment with psychomotor stimulants on specific binding of [3H]dihydroalprenolol to ß-adrenoceptors in rat brain were examined. At a dose of 10 mg/kg both acute and chronic treatment with cocaine and chronic treatment withd-amphetamine (10 mg/kg) caused increased binding of [3H]dihydroalprenolol. The molecular mechanism for this enhanced binding appears to be augmentation of the density of ß-adrenoceptors in rat brain. At a lower dose (5 mg/kg), however, chronic administration ofd-ampethamine caused a decrease in the density of ß-adrenoceptors in rat brain. Chronic treatment with eitherd-amphetamine (10 mg/kg) or cocaine induced a marked increase in the magnitude of cyclic AMP accumulation in rat brain slices elicited by norepinephrine. Acute as well as chronic administration ofd-amphetamine in vivo inhibited the temperature-dependent uptake of [3H]norepinephrine in rat brain synaptosomal homogenates, but no such inhibition was observed after chronic or acute treatment with cocaine. The results suggest that psychomotor stimulants induced ß-adrenoceptor supersensitivity which may be involved in the phenomenon of reverse tolerance and possibly psychosis in humans. The development of ß-adrenoceptor supersensitivity does not appear to be mediated through alterations in norepinephrine transport at the presynaptic sites." @default.
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• W2045196759 date "1979-10-01" @default.
• W2045196759 modified "2023-09-28" @default.
• W2045196759 title "Cocaine andd-amphetamine induce changes in central ß-adrenoceptor sensitivity: Effects of acute and chronic drug treatment" @default.
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• W2045196759 doi "https://doi.org/10.1016/0006-8993(79)90518-3" @default.
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