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- W2045197793 abstract "TGF-beta 1 purified from human platelets induces colony formation of rat fibroblasts reversibly when administered together with EGF. TGF-beta 1 has been reported by us to lead to stable transformation of rat fibroblasts, to activate latent Epstein-Barr virus, to exhibit tumor promoting activity for murine fibroblasts, and to cause the release of apoptosis-inducing signals from normal cells which are directed specifically against transformed cells. The use of recombinant TGF-beta 1 in this study showed that all the effects measured were indeed due to TGF-beta 1. In order to get information on intracellular signal pathways induced by TGF-beta 1, specific inhibitors of protein kinase C (PKC) were applied. Induction of EBV antigens by TGF-beta 1 was dependent on the function of PKC, whereas induction of apoptosis in transformed cells by TGF-beta 1-treated normal cells was independent of the action of PKC." @default.
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- W2045197793 date "1995-09-01" @default.
- W2045197793 modified "2023-09-26" @default.
- W2045197793 title "PKC-DEPENDENT AND PKC-INDEPENDENT CELLULAR EFFECTS INDUCED BY RECOMBINANT TRANSFORMING GROWTH-FACTOR TYPE-BETA-1" @default.
- W2045197793 doi "https://doi.org/10.3892/ijo.7.3.565" @default.
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