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• W2045204629 endingPage "2133" @default.
• W2045204629 startingPage "2124" @default.
• W2045204629 abstract "Akt-mediated signaling plays an important role in blood vascular development. In this study, we investigated the role of Akt in lymphatic growth using Akt-deficient mice. First, we found that lymphangiogenesis occurred in Akt1(-/-), Akt2(-/-), and Akt3(-/-) mice. However, both the diameter and endothelial cell number of lymphatic capillaries were significantly less in Akt1(-/-) mice than in wild-type control mice, whereas there was only a slight change in Akt2(-/-) and Akt3(-/-) mice. Second, valves present in the small collecting lymphatics in the superficial dermal layer of the ear skin were rarely observed in Akt1(-/-) mice, although these valves could be detected in the large collecting lymphatics in the deep layer of the skin tissues. A fluorescence microlymphangiography assay showed that the skin lymphatic network in Akt1(-/-) mice was functional but abnormal as shown by fluorescein isothiocyanate-dextran draining. There was an uncharacteristic enlargement of collecting lymphatic vessels, and further analysis showed that smooth muscle cell coverage of collecting lymphatic vessels became much more sparse in Akt1-deficient mice than in wild-type control animals. Finally, we showed that lymphatic vessels were detected in compound Akt-null mice and that lymphangiogenesis could be induced by vascular endothelial growth factor-C delivered via adenoviral vectors in adult mice lacking Akt1. These results indicate that despite the compensatory roles of other Akt isoforms, Akt1 is more critically required during lymphatic development." @default.
• W2045204629 created "2016-06-24" @default.
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• W2045204629 date "2010-10-01" @default.
• W2045204629 modified "2023-10-18" @default.
• W2045204629 title "Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development" @default.
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• W2045204629 doi "https://doi.org/10.2353/ajpath.2010.091301" @default.
• W2045204629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2947305" @default.
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