Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045204862> ?p ?o ?g. }
- W2045204862 endingPage "179" @default.
- W2045204862 startingPage "169" @default.
- W2045204862 abstract "Although hair cells regenerate spontaneously in birds and lower vertebrates following injury, there is yet no effective way to stimulate hair cell regeneration in mature mammalian inner ears. Here we report that a large number of hair cells are produced in the sensory epithelium of cultured adult rat utricular maculae, via adenovirus-mediated overexpression of Hath1, a human atonal homolog. The generation of new hair cells via Hath1 expression does not involve cell proliferation based on bromodeoxyuridine immunocytochemistry. Furthermore, using a similar approach, hair cells are regenerated following aminoglycoside injury in these cultures. These data show conclusively that mature mammalian inner ears have the competence to produce a large number of new hair cells. Local adenoviral gene therapy in the inner ear may be a potential approach to treatment of hearing and balance disorders." @default.
- W2045204862 created "2016-06-24" @default.
- W2045204862 creator A5054604750 @default.
- W2045204862 creator A5054616509 @default.
- W2045204862 creator A5081148554 @default.
- W2045204862 date "2003-06-01" @default.
- W2045204862 modified "2023-10-18" @default.
- W2045204862 title "Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1" @default.
- W2045204862 cites W1482140147 @default.
- W2045204862 cites W1540057367 @default.
- W2045204862 cites W1542222934 @default.
- W2045204862 cites W1580667945 @default.
- W2045204862 cites W1972538107 @default.
- W2045204862 cites W1975949784 @default.
- W2045204862 cites W1984425391 @default.
- W2045204862 cites W1985835614 @default.
- W2045204862 cites W1991954192 @default.
- W2045204862 cites W1992857468 @default.
- W2045204862 cites W1995048201 @default.
- W2045204862 cites W1998846533 @default.
- W2045204862 cites W2013935392 @default.
- W2045204862 cites W2014144089 @default.
- W2045204862 cites W2024121049 @default.
- W2045204862 cites W2026120980 @default.
- W2045204862 cites W2027150345 @default.
- W2045204862 cites W2028916500 @default.
- W2045204862 cites W2031962975 @default.
- W2045204862 cites W2049279317 @default.
- W2045204862 cites W2051675306 @default.
- W2045204862 cites W2056069458 @default.
- W2045204862 cites W2058261982 @default.
- W2045204862 cites W2091640904 @default.
- W2045204862 cites W2092017486 @default.
- W2045204862 cites W2094065501 @default.
- W2045204862 cites W2098300864 @default.
- W2045204862 cites W2113257602 @default.
- W2045204862 cites W2115613703 @default.
- W2045204862 cites W2129384667 @default.
- W2045204862 cites W2141788881 @default.
- W2045204862 cites W2143331812 @default.
- W2045204862 cites W2147664526 @default.
- W2045204862 cites W2154546815 @default.
- W2045204862 cites W2163857939 @default.
- W2045204862 cites W2166509920 @default.
- W2045204862 cites W2176417291 @default.
- W2045204862 cites W3208720944 @default.
- W2045204862 cites W4238317003 @default.
- W2045204862 cites W95697080 @default.
- W2045204862 doi "https://doi.org/10.1016/s1044-7431(03)00066-6" @default.
- W2045204862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12812751" @default.
- W2045204862 hasPublicationYear "2003" @default.
- W2045204862 type Work @default.
- W2045204862 sameAs 2045204862 @default.
- W2045204862 citedByCount "173" @default.
- W2045204862 countsByYear W20452048622012 @default.
- W2045204862 countsByYear W20452048622013 @default.
- W2045204862 countsByYear W20452048622014 @default.
- W2045204862 countsByYear W20452048622015 @default.
- W2045204862 countsByYear W20452048622016 @default.
- W2045204862 countsByYear W20452048622017 @default.
- W2045204862 countsByYear W20452048622018 @default.
- W2045204862 countsByYear W20452048622019 @default.
- W2045204862 countsByYear W20452048622020 @default.
- W2045204862 countsByYear W20452048622021 @default.
- W2045204862 countsByYear W20452048622022 @default.
- W2045204862 countsByYear W20452048622023 @default.
- W2045204862 crossrefType "journal-article" @default.
- W2045204862 hasAuthorship W2045204862A5054604750 @default.
- W2045204862 hasAuthorship W2045204862A5054616509 @default.
- W2045204862 hasAuthorship W2045204862A5081148554 @default.
- W2045204862 hasConcept C105702510 @default.
- W2045204862 hasConcept C134018914 @default.
- W2045204862 hasConcept C171056886 @default.
- W2045204862 hasConcept C203014093 @default.
- W2045204862 hasConcept C204232928 @default.
- W2045204862 hasConcept C2778260397 @default.
- W2045204862 hasConcept C2778500370 @default.
- W2045204862 hasConcept C2778585322 @default.
- W2045204862 hasConcept C2780130748 @default.
- W2045204862 hasConcept C35866371 @default.
- W2045204862 hasConcept C86803240 @default.
- W2045204862 hasConcept C95444343 @default.
- W2045204862 hasConceptScore W2045204862C105702510 @default.
- W2045204862 hasConceptScore W2045204862C134018914 @default.
- W2045204862 hasConceptScore W2045204862C171056886 @default.
- W2045204862 hasConceptScore W2045204862C203014093 @default.
- W2045204862 hasConceptScore W2045204862C204232928 @default.
- W2045204862 hasConceptScore W2045204862C2778260397 @default.
- W2045204862 hasConceptScore W2045204862C2778500370 @default.
- W2045204862 hasConceptScore W2045204862C2778585322 @default.
- W2045204862 hasConceptScore W2045204862C2780130748 @default.
- W2045204862 hasConceptScore W2045204862C35866371 @default.
- W2045204862 hasConceptScore W2045204862C86803240 @default.
- W2045204862 hasConceptScore W2045204862C95444343 @default.
- W2045204862 hasIssue "2" @default.
- W2045204862 hasLocation W20452048621 @default.
- W2045204862 hasLocation W20452048622 @default.
- W2045204862 hasOpenAccess W2045204862 @default.