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- W2045207841 abstract "When human peripheral blood B cells are cultured for 6 days with the T cell-dependent peptide antigen ovalbumin (OA) in the presence of antigen-presenting cells and helper T cells, plaque-forming cells (PFC) are generated. These OA-induced PFC differ from the conventional high-rate antibody-secreting PFC formed after stimulation of B cells with recall antigens (e.g. tetanus toxoid) in that they secrete antibody at a very low level. Previous studies have shown that OA-induced PFC are B lymphocytes in an early activation state rather than cells that have differentiated into plasmablasts. The apparent arrest in the maturation of OA-induced PFC in an early activation phase can be overcome by simultaneous stimulation with interleukin 2 (IL-2) and gamma interferon (IFN-gamma). The isotype of the OA-specific antibodies secreted, however, are only of the IgM class, demonstrating that an isotype switch does not occur." @default.
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- W2045207841 date "1988-11-01" @default.
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- W2045207841 title "Generation of High-Rate Ovalbumin-Specific Antibody-Secreting Cells in Cultures of Human Peripheral Blood B Cells Obtained from Non-Immunized Blood Donors" @default.
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- W2045207841 doi "https://doi.org/10.1111/j.1365-3083.1988.tb01490.x" @default.
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