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- W2045212858 abstract "This review focuses on the role of interleukin (IL)-12, a proinflammatory cytokine with pleiotropic effects as a potent immunoregulatory molecule and hematopoietic growth factor, in infection with Plasmodium parasites, the causative agents of malaria. IL-12 has been demonstrated to have profound effects on the immune response to blood-stage malaria, to induce protection, and to alleviate malarial anemia. In combination with an anti-malarial drug, IL-12 is effective in an established malaria infection. This cytokine also has potent immune effects as a malaria vaccine adjuvant. However, IL-12 can also mediate pathology during blood-stage malaria." @default.
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- W2045212858 date "2001-01-01" @default.
- W2045212858 modified "2023-10-17" @default.
- W2045212858 title "Modulation of host responses to blood-stage malaria by interleukin-12: from therapyto adjuvant activity" @default.
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- W2045212858 doi "https://doi.org/10.1016/s1286-4579(00)01354-x" @default.
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