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• W2045222512 startingPage "1" @default.
• W2045222512 abstract "The progression of normal cells to a tumorigenic and metastatic state involves the accumulation of mutations in multiple key signaling proteins, encoded by oncogenes and tumor suppressor genes. Recently, members of the TRP channel family have been included in the oncogenic and tumor suppressor protein family. TRPM1, TRPM8, and TRPV6 are considered to be tumor suppressors and oncogenes in localized melanoma and prostate cancer, respectively. Herein, we focus our attention on the antioncogenic properties of TRPV1. Changes in TRPV1 expression occur during the development of transitional cell carcinoma (TCC) of human bladder. A progressive decrease in TRPV1 expression as the TCC stage increases triggers the development of a more aggressive gene phenotype and invasiveness. Finally, downregulation of TRPV1 represents a negative prognostic factor in TCC patients. The knowledge of the mechanism controlling TRPV1 expression might improve the diagnosis and new therapeutic strategies in bladder cancer." @default.
• W2045222512 created "2016-06-24" @default.
• W2045222512 creator A5015143100 @default.
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• W2045222512 creator A5032531876 @default.
• W2045222512 creator A5055035695 @default.
• W2045222512 creator A5079690240 @default.
• W2045222512 date "2012-02-06" @default.
• W2045222512 modified "2023-10-02" @default.
• W2045222512 title "Antioncogenic Effects of Transient Receptor Potential Vanilloid 1 in the Progression of Transitional Urothelial Cancer of Human Bladder" @default.
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• W2045222512 doi "https://doi.org/10.5402/2012/458238" @default.
• W2045222512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3302024" @default.
• W2045222512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22523714" @default.
• W2045222512 hasPublicationYear "2012" @default.
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