FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045233003> ?p ?o ?g. }

• W2045233003 endingPage "48" @default.
• W2045233003 startingPage "41" @default.
• W2045233003 abstract "Anemia is an important negative predictor for survival with disseminated Mycobacterium avium complex (MAC) infection in the acquired immunodeficiency syndrome (AIDS). We analyzed the differences in AIDS patients with and without MAC infection with regard to anemia, severity of human immunodeficiency virus (HIV) infection, bone marrow morphology, and bone marrow erythroid progenitor colony growth (BFU-E and CFU-E). In addition, we determined the in vitro effect of sera obtained from these patients on normal BFU-E and CFU-E. A possible role of macrophages in the suppression of erythropoiesis was examined by studying in vitro the effect of supernatants from MAC-infected macrophages on cultured BFU-E and CFU-E.Hematocrit, serum levels of p24 antigen, erythropoietin, and CD4-positive cell count were determined in 14 AIDS patients with and 24 without MAC infection. Bone marrow erythropoietic and granulocytic progenitor cells from 15 normal individuals, from 12 AIDS patients with MAC infection, and from 10 AIDS patients without MAC infection were cultured on methylcellulose. In addition, progenitor cells from normal individuals were cultured in the presence, and in the absence, of sera obtained from AIDS patients with (14), or without (24), MAC infection. Last, we studied the effect of supernatants (SNs) from MAC and Mycobacterium tuberculosis-infected macrophages on erythropoietic progenitor cell growth.The anemia in AIDS patients with MAC infection was associated with a selective suppression of erythropoietic progenitors despite bone marrow morphology that was indistinguishable from that in patients without MAC infection. The degree of anemia could not be explained on the basis of severity of HIV infection or a deficiency of erythropoietin production. Bone marrow mononuclear cells from AIDS patients with MAC generated significantly fewer erythroid progenitor colonies (BFU-E and CFU-E) than equivalent cells from AIDS patients without MAC infection (p < 0.05). Sera from MAC-infected AIDS patients were markedly inhibitory to the erythroid progenitors as compared with sera from patients without MAC infection (p < 0.001). SNs from MAC-infected macrophages were markedly inhibitory to the erythroid progenitors (BFU-E and CFU-E) as compared with the myeloid progenitors (CFU-GM).The profound anemia in MAC-infected AIDS patients is due to suppression of erythroid progenitors by a soluble factor(s) in the serum. The data suggest that the soluble factor(s) is probably elaborated by macrophages." @default.
• W2045233003 created "2016-06-24" @default.
• W2045233003 creator A5007556722 @default.
• W2045233003 creator A5066050468 @default.
• W2045233003 creator A5085147005 @default.
• W2045233003 date "1993-01-01" @default.
• W2045233003 modified "2023-10-18" @default.
• W2045233003 title "Impaired erythropoiesis in the acquired immunodeficiency syndrome with disseminated Mycobacterium avium complex" @default.
• W2045233003 cites W1931314445 @default.
• W2045233003 cites W1943019381 @default.
• W2045233003 cites W1945469767 @default.
• W2045233003 cites W1975811341 @default.
• W2045233003 cites W1979989842 @default.
• W2045233003 cites W1983516873 @default.
• W2045233003 cites W1997169389 @default.
• W2045233003 cites W2014042634 @default.
• W2045233003 cites W2022854476 @default.
• W2045233003 cites W2029321219 @default.
• W2045233003 cites W2036890038 @default.
• W2045233003 cites W2042546198 @default.
• W2045233003 cites W2066121768 @default.
• W2045233003 cites W2105172448 @default.
• W2045233003 cites W2163237181 @default.
• W2045233003 cites W2171933443 @default.
• W2045233003 cites W2397156964 @default.
• W2045233003 cites W2409748702 @default.
• W2045233003 cites W2414324067 @default.
• W2045233003 cites W2462427044 @default.
• W2045233003 cites W4239861675 @default.
• W2045233003 cites W4246333258 @default.
• W2045233003 cites W4249129130 @default.
• W2045233003 cites W4376044059 @default.
• W2045233003 doi "https://doi.org/10.1016/0002-9343(93)90118-9" @default.
• W2045233003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8093587" @default.
• W2045233003 hasPublicationYear "1993" @default.
• W2045233003 type Work @default.
• W2045233003 sameAs 2045233003 @default.
• W2045233003 citedByCount "30" @default.
• W2045233003 countsByYear W20452330032015 @default.
• W2045233003 countsByYear W20452330032017 @default.
• W2045233003 countsByYear W20452330032018 @default.
• W2045233003 countsByYear W20452330032021 @default.
• W2045233003 countsByYear W20452330032022 @default.
• W2045233003 crossrefType "journal-article" @default.
• W2045233003 hasAuthorship W2045233003A5007556722 @default.
• W2045233003 hasAuthorship W2045233003A5066050468 @default.
• W2045233003 hasAuthorship W2045233003A5085147005 @default.
• W2045233003 hasConcept C126322002 @default.
• W2045233003 hasConcept C159047783 @default.
• W2045233003 hasConcept C201750760 @default.
• W2045233003 hasConcept C203014093 @default.
• W2045233003 hasConcept C2776175824 @default.
• W2045233003 hasConcept C2778248108 @default.
• W2045233003 hasConcept C2778534260 @default.
• W2045233003 hasConcept C2779703530 @default.
• W2045233003 hasConcept C2780007613 @default.
• W2045233003 hasConcept C28328180 @default.
• W2045233003 hasConcept C54355233 @default.
• W2045233003 hasConcept C71924100 @default.
• W2045233003 hasConcept C86803240 @default.
• W2045233003 hasConceptScore W2045233003C126322002 @default.
• W2045233003 hasConceptScore W2045233003C159047783 @default.
• W2045233003 hasConceptScore W2045233003C201750760 @default.
• W2045233003 hasConceptScore W2045233003C203014093 @default.
• W2045233003 hasConceptScore W2045233003C2776175824 @default.
• W2045233003 hasConceptScore W2045233003C2778248108 @default.
• W2045233003 hasConceptScore W2045233003C2778534260 @default.
• W2045233003 hasConceptScore W2045233003C2779703530 @default.
• W2045233003 hasConceptScore W2045233003C2780007613 @default.
• W2045233003 hasConceptScore W2045233003C28328180 @default.
• W2045233003 hasConceptScore W2045233003C54355233 @default.
• W2045233003 hasConceptScore W2045233003C71924100 @default.
• W2045233003 hasConceptScore W2045233003C86803240 @default.
• W2045233003 hasIssue "1" @default.
• W2045233003 hasLocation W20452330031 @default.
• W2045233003 hasLocation W20452330032 @default.
• W2045233003 hasOpenAccess W2045233003 @default.
• W2045233003 hasPrimaryLocation W20452330031 @default.
• W2045233003 hasRelatedWork W1980002707 @default.
• W2045233003 hasRelatedWork W2069741494 @default.
• W2045233003 hasRelatedWork W2093825344 @default.
• W2045233003 hasRelatedWork W2115738539 @default.
• W2045233003 hasRelatedWork W288083045 @default.
• W2045233003 hasRelatedWork W3134756449 @default.
• W2045233003 hasRelatedWork W343388333 @default.
• W2045233003 hasRelatedWork W4211235902 @default.
• W2045233003 hasRelatedWork W4383708651 @default.
• W2045233003 hasRelatedWork W53896844 @default.
• W2045233003 hasVolume "94" @default.
• W2045233003 isParatext "false" @default.
• W2045233003 isRetracted "false" @default.
• W2045233003 magId "2045233003" @default.
• W2045233003 workType "article" @default.