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- W2045233609 abstract "Eight-month-old random bred Romney wethered lambs were reared nematode-free in pens and assigned to 4 groups of 5 lambs. Lambs in 2 groups were dosed orally, twice a week, with 5000 Trichostrongylus colubriformis infective larvae (L3) for the duration of the experiment. These 2 groups were treated weekly with dexamethasone (0.5mg kg−1 body-weight), one between days −7 and 70, the other between days 77 and 147. A third group was dosed with L3 until anthelmintic treatment on day 133. A fourth group remained uninfected throughout and served as a control group. Nematode eggs in sheep faeces (FEC) were monitored at weekly intervals. Serum samples were taken twice a week and assayed for sheep mast cell proteinase (SMCP). Serum levels of SMCP in uninfected control sheep were 459 ± 190 pg ml−1. Twenty-eight days after nematode dosing commenced, SMCP levels were significantly above control sheep levels and after 49 days reached a plateau level of 1154±364 pg ml−1. The SMCP response persisted even after cessation of dosing, and SMCP levels remained significantly above control levels to the end of the experiment (day 213). Dexamethasone treatment prevented elevation of SMCP and resulted in a rapid reduction of extant SMCP levels in resistant sheep. Overall, serum levels of SMCP were significantly correlated (P < 0.001) with specific anti-T. colubriformis L3 antibody in serum (r = 0.601, d.f. = 78), blood eosinophils (r = 0.609, d.f. = 78) and log(FEC+15) (r = −0.521, d.f. = 78). These results show that serum levels of SMCP correlate with other indicators of parasitism and may have potential use as a non-invasive indicator of gastro-intestinal mast cell responses to nematode infection." @default.
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- W2045233609 title "Serum mast cell proteinase responses of sheep to challenge with Trichostrongylus colubriformis and the effect of dexamethasone treatment" @default.
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- W2045233609 doi "https://doi.org/10.1016/0020-7519(95)00086-0" @default.
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